| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ARC16-2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ARPC5L |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下为基于ARPC5L相关研究的模拟参考文献示例(实际文献需通过学术数据库验证)：
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1. **标题**：*ARPC5L Deficiency Disrupts Actin Polymerization in T Cells and Causes Immunodeficiency*
**作者**：Smith A, et al.
**摘要**：研究发现ARPC5L基因突变导致Arp2/3复合体功能异常，影响T细胞中肌动蛋白聚合，引发严重的联合免疫缺陷综合征。研究通过ARPC5L特异性抗体验证了蛋白表达缺失与疾病表型的关联。
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2. **标题**：*ARPC5L Promotes Metastatic Invasion in Melanoma via Actin Network Remodeling*
**作者**：Chen L, et al.
**摘要**：本文揭示ARPC5L在黑色素瘤转移中通过调控Arp2/3复合体介导的细胞伪足形成促进侵袭。使用ARPC5L抗体进行免疫荧光实验，证实其高表达与患者预后不良相关。
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3. **标题**：*Functional Characterization of ARPC5L in Neutrophil Migration*
**作者**：Wang Y, et al.
**摘要**：研究利用CRISPR敲除和ARPC5L抗体阻断实验，证明ARPC5L缺失会显著抑制中性粒细胞趋化迁移能力，为炎症性疾病治疗提供了潜在靶点。
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4. **标题**：*ARPC5L Regulates Autophagosome Formation through Actin Dynamics*
**作者**：Tanaka K, et al.
**摘要**：该研究提出ARPC5L通过调控肌动蛋白骨架影响自噬体形成，ARPC5L抗体结合实验显示其与自噬相关蛋白的相互作用，为癌症和神经退行性疾病机制研究提供新视角。
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**注意**：以上文献为示例性内容，实际研究中需通过PubMed、Google Scholar等平台检索真实文献(关键词：ARPC5L antibody, Arp2/3 complex, actin cytoskeleton)。
The ARPC5L (Actin-Related Protein 2/3 Complex Subunit 5-Like) antibody is a tool used to detect the ARPC5L protein, a component of the Actin-Related Protein 2/3 (ARP2/3) complex. This evolutionarily conserved complex plays a critical role in nucleating branched actin filament networks, which drive cellular processes like membrane protrusion, cell migration, and vesicular trafficking. ARPC5L, along with its paralog ARPC5. forms a heterodimer that stabilizes the ARP2/3 complex and enhances its actin-nucleating activity. While ARPC5 is ubiquitously expressed, ARPC5L exhibits tissue-specific expression, with higher levels in immune cells, testis, and spleen, suggesting specialized roles in immune regulation or spermatogenesis.
Studies using ARPC5L antibodies have helped elucidate its involvement in cytoskeletal dynamics and disease contexts. For instance, ARPC5L dysfunction has been linked to hematopoietic abnormalities, including T-cell deficiency and platelet anomalies, as well as certain cancers marked by aberrant cell motility. The antibody is commonly employed in techniques like Western blotting, immunofluorescence, and immunohistochemistry to assess ARPC5L expression levels, localization, and interactions. Its development has facilitated research into how ARP2/3-mediated actin remodeling contributes to physiological processes (e.g., immune cell activation) and pathological conditions (e.g., metastatic invasion). Validation of ARPC5L antibody specificity remains essential, given the high homology between ARPC5L and ARPC5.
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