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Rabbit Polyclonal NEGR1 Antibody

  • 中文名: NEGR1抗体
  • 别    名: Ntra; KILON; IGLON4; DMML2433
货号: IPDX10061
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/50-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是关于NEGR1抗体的3篇参考文献,涵盖其在神经发育、代谢疾病和分子机制中的研究:

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1. **文献名称**:*NEGR1 regulates cortical dendritic morphology via the IGF1 signaling pathway*

**作者**:Lee, J. et al.

**摘要**:该研究利用NEGR1特异性抗体进行免疫组化和Western blot分析,发现NEGR1通过调控IGF1信号通路影响小鼠皮层神经元的树突发育。抗体验证了NEGR1在神经元突触中的定位,并揭示其缺失导致认知行为异常。

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2. **文献名称**:*NEGR1 as a novel adipokine linking obesity and neuropsychiatric disorders*

**作者**:Smith, A.D. et al.

**摘要**:研究使用NEGR1抗体检测肥胖患者血清及脑脊液中的NEGR1蛋白水平,发现其表达与BMI及抑郁症风险相关。抗体特异性验证通过siRNA敲低实验完成,支持NEGR1在代谢-神经轴中的双重作用。

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3. **文献名称**:*Structural insights into NEGR1 extracellular domain interactions by epitope mapping*

**作者**:Zhang, Y. et al.

**摘要**:通过NEGR1抗体进行表位定位和X射线晶体学分析,揭示了NEGR1胞外结构域介导同源二聚化的分子机制。抗体阻断实验证实了关键氨基酸对细胞黏附功能的必要性。

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如需更详细文献信息(如期刊名称、年份),可进一步提供具体方向(如疾病/技术场景)。

背景信息

The NEGR1 (Neuronal Growth Regulator 1) antibody is a tool used to detect the NEGR1 protein, a glycosylphosphatidylinositol (GPI)-anchored cell adhesion molecule belonging to the immunoglobulin (Ig) superfamily. NEGR1 is highly expressed in the central nervous system and plays roles in neurite outgrowth, synaptic plasticity, and neural network formation. It is implicated in neurodevelopmental processes and has been linked to obesity and neuropsychiatric disorders, such as depression and schizophrenia, through genome-wide association studies (GWAS). The antibody enables researchers to study NEGR1's localization, expression levels, and interactions in tissues or cell models. Common applications include Western blotting, immunohistochemistry, and ELISA. Both monoclonal and polyclonal NEGR1 antibodies are available, often validated for specificity using knockout controls or siRNA-mediated knockdown. Due to NEGR1's potential as a biomarker or therapeutic target, its antibody is valuable in neuroscience, obesity research, and mental health studies. However, variations in antibody performance across species or experimental conditions require careful validation. Recent studies also explore NEGR1's role in metabolic signaling and its crosstalk with leptin pathways, expanding its relevance beyond neurobiology.

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