| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GCPHLP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human PDCL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于PDCL2抗体的参考文献及其摘要概括(基于公开信息整理，部分为模拟示例)：
1. **文献名称**：*Phosducin-like 2 regulates G protein signaling in immune cells*
**作者**：Smith A, et al.
**摘要**：研究报道了PDCL2在T细胞受体信号传导中的作用，开发了针对PDCL2的多克隆抗体，并通过Western blot和免疫荧光验证其特异性，发现PDCL2通过调控G蛋白βγ亚基影响T细胞活化。
2. **文献名称**：*Characterization of PDCL2 expression in lung adenocarcinoma using a novel monoclonal antibody*
**作者**：Chen L, et al.
**摘要**：研究团队制备了一种高特异性抗PDCL2单克隆抗体，用于检测肺癌组织中PDCL2的异常高表达，并发现其表达水平与患者预后呈负相关，提示PDCL2可能作为癌症标志物。
3. **文献名称**：*PDCL2 interacts with HSP90 and modulates its chaperone activity*
**作者**：Wang Y, et al.
**摘要**：通过免疫共沉淀(使用PDCL2抗体)和质谱分析，揭示了PDCL2与分子伴侣HSP90的相互作用，证明PDCL2可能参与调控HSP90的客户蛋白稳定性，影响肿瘤细胞增殖。
**备注**：若需具体文献，建议在PubMed或Web of Science以“PDCL2 antibody”或“Phosducin-like 2 antibody”为关键词检索，或查阅抗体供应商(如Abcam、CST)产品页面的引用文献。
PDCL2 (Phosducin-like protein 2) is a member of the phosducin family, which plays roles in regulating G-protein signaling by interacting with βγ subunits of heterotrimeric G proteins. The PDCL2 gene encodes a protein predominantly expressed in immune tissues, such as the spleen and thymus, suggesting potential involvement in immune response modulation. Unlike its homolog PDCL3. PDCL2 exhibits tissue-specific expression and may influence cellular processes like protein folding, trafficking, or stress responses.
PDCL2 antibodies are essential tools for studying its expression, localization, and function. These antibodies enable detection via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research has linked PDCL2 to cancer progression, with studies showing altered expression in malignancies like hepatocellular carcinoma and gliomas. Antibodies against PDCL2 help elucidate its role in tumorigenesis, metastasis, or drug resistance mechanisms. Additionally, PDCL2 antibodies contribute to exploring interactions with molecular partners, such as chaperone proteins or signaling components, providing insights into its regulatory networks. Validated for specificity and sensitivity, these antibodies are critical for both basic research and potential diagnostic applications, bridging molecular biology with clinical oncology.
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