| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human MAMDC2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于MAMDC2抗体的3篇参考文献的简要信息(注：由于MAMDC2研究较为小众，部分文献可能为假设性示例，实际文献需通过学术数据库验证)：
---
1. **文献名称**：*MAMDC2 as a Novel Biomarker in Colorectal Cancer: Expression Analysis Using a Specific Polyclonal Antibody*
**作者**：Smith A, et al.
**摘要**：本研究开发了一种针对MAMDC2蛋白的多克隆抗体，并通过免疫组化证实MAMDC2在结直肠癌组织中的高表达。结果显示，MAMDC2的高表达与患者预后不良相关，提示其可能作为结直肠癌的潜在生物标志物。
2. **文献名称**：*Functional Characterization of MAMDC2 in Melanoma Progression via Antibody-Mediated Knockdown*
**作者**：Lee J, et al.
**摘要**：通过构建MAMDC2特异性抗体，研究团队发现抑制MAMDC2可降低黑色素瘤细胞的侵袭和转移能力。实验表明，MAMDC2通过调控TGF-β信号通路促进肿瘤进展。
3. **文献名称**：*MAMDC2 Antibody Validation for Flow Cytometry and Western Blot Applications*
**作者**：Chen R, et al.
**摘要**：本文验证了商业化的MAMDC2单克隆抗体在流式细胞术和Western blot中的特异性，确认其在多种细胞系中可稳定检测MAMDC2蛋白表达，为后续功能研究提供了可靠工具。
---
**说明**：以上文献为示例性质，若需真实文献，建议通过PubMed或Google Scholar检索关键词“MAMDC2 antibody”或联系抗体生产商(如Abcam、Thermo Fisher)获取相关技术文献。
The MAMDC2 (MAM domain-containing protein 2) antibody is a tool used to detect the MAMDC2 protein, which belongs to the MAM (Meprin/A5 protein/PTPmu) domain-containing family. This conserved domain is implicated in cell adhesion, receptor signaling, and extracellular interactions. MAMDC2. also known as MDGA2. is a transmembrane or secreted glycoprotein involved in regulating cell-cell communication, neuronal development, and synaptic organization. Studies suggest its potential role in modulating the Slit-Robo signaling pathway, which influences axon guidance and neural circuit formation.
The antibody is typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. It enables researchers to study MAMDC2's expression patterns, localization, and function in tissues, particularly in the nervous system. Applications include Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Validation often involves knockout controls or siRNA-mediated silencing to confirm specificity.
While MAMDC2's biological significance remains under investigation, its dysregulation has been tentatively linked to neurodevelopmental disorders and cancer metastasis. The antibody thus serves as a critical reagent for exploring MAMDC2's mechanistic roles in health and disease. Recent studies also highlight its interaction with extracellular matrix components, suggesting involvement in tissue remodeling processes.
×
