| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | THTP; THTPASE |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human THTPA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于THTPA抗体的虚拟参考文献示例(注：THTPA相关研究较少，可能涉及拼写混淆，请核实目标分子名称)：
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1. **文献名称**: *THTPA Antibody as a Novel Biomarker in Autoimmune Encephalitis*
**作者**: Zhang L, et al.
**摘要**: 本研究报道THTPA抗体在自身免疫性脑炎患者血清中的特异性表达，发现其与神经元表面抗原的交叉反应可能参与疾病病理机制，提示其作为潜在诊断标志物的价值。
2. **文献名称**: *Development of a High-Sensitivity ELISA for Detecting Anti-THTPA Antibodies*
**作者**: Müller S, et al.
**摘要**: 团队开发了一种基于重组THTPA蛋白的ELISA检测方法，用于定量分析血清中的THTPA抗体，验证了其在类风湿关节炎患者中的阳性率显著高于健康对照组。
3. **文献名称**: *THTPA Antibody-Mediated Signal Disruption in Cancer Cell Apoptosis*
**作者**: Kim J, et al.
**摘要**: 实验证明THTPA抗体可通过阻断细胞内THTPA蛋白的磷酸化通路，抑制肿瘤细胞增殖并诱导凋亡，为靶向治疗提供了新思路。
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**注意**：以上内容为模拟生成，实际研究中THTPA相关文献较少。建议确认目标分子是否为**TDP-43(TAR DNA-binding protein 43)**、**TPO(甲状腺过氧化物酶)**或其他常见抗体靶点，或提供更多背景信息以便准确检索。
The THTPA antibody, likely referring to thyroid peroxidase (TPO) antibody, is an autoantibody targeting thyroid peroxidase, a key enzyme in thyroid hormone synthesis. TPO antibodies are central to autoimmune thyroid disorders, such as Hashimoto's thyroiditis and Graves' disease. In Hashimoto's, they contribute to gland destruction by triggering immune-mediated inflammation, leading to hypothyroidism. In Graves' disease, they may coexist with TSH receptor antibodies, though their role here is less direct.
Clinically, TPO antibody detection aids in diagnosing autoimmune thyroiditis, especially when thyroid function tests are ambiguous. Elevated levels are also prognostic markers; for instance, in euthyroid individuals, they indicate higher risks of developing overt hypothyroidism. During pregnancy, their presence is linked to postpartum thyroiditis and potential adverse outcomes like miscarriage or preterm birth.
Testing involves immunoassays, with titers correlating to disease severity. While not targeted therapeutically, their detection guides management, such as thyroid function monitoring or levothyroxine initiation in subclinical hypothyroidism. Research continues to explore their pathogenic mechanisms, including molecular mimicry or genetic susceptibility (e.g., HLA-DR variants). Overall, TPO antibodies serve as critical biomarkers in understanding and managing thyroid autoimmunity.
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