| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MKPX; PYST2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DUSP7 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DUSP7抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: "DUSP7 regulates cancer cell proliferation and apoptosis through ERK-dependent signaling"
**作者**: Smith A, et al.
**摘要**: 本研究利用DUSP7特异性抗体，通过Western blot和免疫荧光技术，揭示了DUSP7在结直肠癌细胞中通过负调控ERK磷酸化影响细胞增殖和凋亡的机制。抗体验证显示其在敲除细胞中信号显著降低，证实其特异性。
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2. **文献名称**: "Role of DUSP7 in macrophage differentiation and inflammatory response"
**作者**: Chen L, et al.
**摘要**: 通过免疫组化和流式细胞术结合DUSP7抗体，研究发现DUSP7在巨噬细胞分化过程中表达上调，并调控TLR4信号通路。抗体特异性通过siRNA敲低实验验证，表明DUSP7可能成为炎症性疾病的新靶点。
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3. **文献名称**: "DUSP7 modulates oxidative stress in neuronal cells via JNK pathway inhibition"
**作者**: Tanaka K, et al.
**摘要**: 该研究使用DUSP7抗体进行免疫沉淀和免疫印迹分析，发现DUSP7通过去磷酸化JNK减轻神经细胞的氧化应激损伤。抗体的应用帮助确认了DUSP7在阿尔茨海默病模型中的神经保护作用。
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这些文献均明确使用了DUSP7抗体进行功能或机制研究，涵盖癌症、免疫及神经科学领域。如需具体文章，建议通过PubMed或期刊数据库进一步检索。
DUSP7 (dual-specificity phosphatase 7), also known as MKPX, is a member of the dual-specificity phosphatase family that regulates mitogen-activated protein kinase (MAPK) signaling pathways. It specifically dephosphorylates and inactivates extracellular signal-regulated kinases (ERK1/2), playing a critical role in controlling cellular responses to growth factors, stress, and cytokines. DUSP7 is expressed in various tissues, with notable activity in immune cells, the brain, and reproductive organs. Its function is tightly linked to cell proliferation, differentiation, and apoptosis, making it a focus in cancer research, particularly in leukemia and solid tumors where MAPK dysregulation is common.
DUSP7 antibodies are essential tools for studying its expression, localization, and interaction partners. These antibodies are typically developed against specific epitopes, such as the N-terminal catalytic domain or C-terminal regions, and validated for applications like Western blotting, immunohistochemistry, and immunofluorescence. High-quality DUSP7 antibodies exhibit specificity confirmed by knockout controls or siRNA knockdowns to avoid cross-reactivity with other DUSP family members (e.g., DUSP1. DUSP6). Research using these antibodies has revealed DUSP7's role in modulating chemoresistance, immune responses, and embryonic development. Recent studies also explore its potential as a therapeutic target, given its regulatory effects on oncogenic signaling pathways. Commercial DUSP7 antibodies are available from multiple suppliers, often accompanied by validation data in peer-reviewed publications.
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