Rabbit Polyclonal SETMAR Antibody

中文名： SETMAR抗体
别名： Mar1; METNASE

货号: IPDX10115

Price： ￥1180

50μl 100μl

数量：

大包装询价

验证与应用

应用及物种

WB	咨询技术	Human,Mouse,Rat
IF	咨询技术	Human,Mouse,Rat
IHC	1/50-1/300	Human,Mouse,Rat
ICC	技术咨询	Human,Mouse,Rat
FCM	咨询技术	Human,Mouse,Rat
Elisa	1/5000-1/10000	Human,Mouse,Rat

产品详情

Aliases	Mar1; METNASE
Host/Isotype	Rabbit IgG
Antibody Type	Primary antibody
Storage	Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity	Human, Mouse
Immunogen	Fusion protein of human SETMAR
Formulation	Purified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P10115(SETMAR Antibody) at dilution 1/60. (Original magnification: ×200)

参考文献

以下是关于SETMAR抗体的示例参考文献(注：以下内容为示例，非真实存在的文献)：

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1. **"Development of a High-Specificity Monoclonal Antibody for Human SETMAR Detection"**

*Authors: Zhang L., et al.*

**摘要**: 本研究报道了一种针对人源SETMAR蛋白的单克隆抗体的开发与验证。通过免疫印迹和免疫荧光实验，验证了该抗体在多种细胞系中的特异性，可用于检测内源性SETMAR的表达及亚细胞定位，为后续功能研究提供工具。

2. **"SETMAR Antibody Reveals Its Dual Role in DNA Repair and Transcriptional Regulation"**

*Authors: Patel R., Smith T.*

**摘要**: 利用特异性SETMAR抗体，研究者发现SETMAR通过结合DNA损伤位点(如双链断裂)参与非同源末端连接修复，同时通过染色质免疫沉淀(ChIP)证明其与组蛋白修饰酶相互作用，提示其在表观遗传调控中的功能。

3. **"Overexpression of SETMAR in Glioblastoma: Prognostic Implications Validated by Immunohistochemistry"**

*Authors: Kim J., et al.*

**摘要**: 通过商业化SETMAR抗体对胶质母细胞瘤组织进行免疫组化分析，发现SETMAR在肿瘤组织中显著高表达，且与患者生存期缩短相关，表明其作为潜在生物标志物的价值。

4. **"Characterization of SETMAR Antibody for Chromatin Interaction Studies"**

*Authors: García M., et al.*

**摘要**: 本文系统评估了多克隆SETMAR抗体在染色质结合实验中的适用性，验证了其在染色质免疫沉淀测序(ChIP-seq)中的特异性，揭示了SETMAR在端粒区域染色质重塑中的新作用。

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**注意**：以上文献为模拟示例，实际研究中请通过学术数据库(如PubMed、Web of Science)检索真实发表的论文。

背景信息

The SETMAR antibody is a research tool designed to study the SETMAR protein, a primate-specific fusion gene product resulting from the merger of a histone methyltransferase (SET) domain and a mariner transposase (MAR) during primate evolution. Found exclusively in humans and some higher primates, SETMAR retains dual functional domains: the N-terminal SET domain, which exhibits histone methyltransferase activity involved in chromatin remodeling, and the C-terminal mariner-derived transposase domain, though the transposase activity is largely inactive in humans.

SETMAR plays roles in DNA repair, transcriptional regulation, and genome stability. It’s implicated in non-homologous end joining (NHEJ) repair and interacts with proteins like Ku70/Ku80. Dysregulation of SETMAR has been linked to cancer progression, neurological disorders, and viral infection responses. Its overexpression in certain cancers correlates with poor prognosis and chemoresistance, suggesting oncogenic potential.

Antibodies targeting SETMAR are used to investigate its expression patterns, subcellular localization, and molecular interactions in cellular models or clinical samples. These tools help clarify its controversial roles—whether tumor-promoting or tumor-suppressing—in different contexts. Commercial SETMAR antibodies are typically validated for applications like Western blotting, immunohistochemistry, and immunofluorescence, aiding both basic research and translational studies exploring SETMAR as a potential therapeutic target.