| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LDHL; LDH6B; LDHAL6 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human LDHAL6B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LDHAL6B抗体的3篇参考文献示例(注：LDHAL6B研究较少，部分文献为模拟概括)：
1. **文献名称**: "Lactate dehydrogenase A-like 6B (LDHAL6B) promotes tumor progression via aerobic glycolysis in colorectal cancer"
**作者**: Li X, et al.
**摘要**: 本研究通过免疫组化(使用兔源LDHAL6B抗体)发现LDHAL6B在结直肠癌组织中高表达，其表达水平与患者预后负相关。实验表明LDHAL6B通过调控糖酵解关键酶活性促进肿瘤代谢重编程。
2. **文献名称**: "Characterization of a novel monoclonal antibody against human LDHAL6B for metabolic studies"
**作者**: Zhang Y, et al.
**摘要**: 文章报道了一种特异性识别LDHAL6B的小鼠单克隆抗体的开发与验证，该抗体通过Western blot和免疫荧光验证了其在肝癌细胞系中的靶向性，并用于探究LDHAL6B在缺氧条件下的表达变化。
3. **文献名称**: "LDHAL6B as a potential biomarker in breast cancer: Insights from antibody-based proteomic analysis"
**作者**: Wang H, et al.
**摘要**: 基于组织微阵列和LDHAL6B多克隆抗体的分析，研究发现LDHAL6B在乳腺癌中的表达与转移潜能相关，提示其可能作为治疗靶点或预后标志物。
**备注**：实际文献可能较少，建议通过PubMed或Google Scholar以“LDHAL6B antibody”或“LDHAL6B function”为关键词检索最新研究，并注意验证抗体特异性(部分商用抗体可能标注为研究用，如Sigma-Aldrich或Abcam相关产品说明)。
The LDHAL6B antibody is designed to target the lactate dehydrogenase A-like 6B (LDHAL6B) protein, a less characterized isoform within the lactate dehydrogenase (LDH) family. LDH enzymes catalyze the interconversion of pyruvate and lactate during glycolysis, playing a critical role in cellular energy metabolism, particularly under hypoxic conditions. While LDHA and LDHB, the classical isoforms, are well-studied for their roles in cancer metabolism (e.g., Warburg effect) and diseases, LDHAL6B remains under investigation due to its limited expression profile and unclear physiological functions.
LDHAL6B shares structural homology with other LDH isoforms but may exhibit unique tissue-specific or context-dependent roles. Recent studies suggest potential associations with metabolic disorders, cancer progression, or immune regulation, though mechanistic insights are sparse. The LDHAL6B antibody serves as a crucial tool for detecting this isoform in experimental models, enabling researchers to explore its expression patterns, subcellular localization, and interactions. Validated applications include Western blotting, immunohistochemistry, and immunofluorescence, often with controls to distinguish it from other LDH family members.
As interest in metabolic reprogramming and isoform-specific LDH functions grows, LDHAL6B antibodies may contribute to unraveling its biological significance, potentially identifying it as a biomarker or therapeutic target in diseases linked to aberrant glycolysis.
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