| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | KIR1.2; KIR4.1; SESAME; BIRK-10; KCNJ13-PEN |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human KCNJ10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于KCNJ10抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*Autoantibodies against astrocytic KIR4.1 (KCNJ10) in multiple sclerosis*
**作者**：Srivastava R, et al.
**摘要**：该研究首次报道在多发性硬化症(MS)患者血清中检测到针对星形胶质细胞钾通道KIR4.1(KCNJ10)的自身抗体，提示其可能通过破坏血脑屏障和离子稳态参与MS的病理机制。
2. **文献名称**：*KCNJ10 mutations and EAST syndrome*
**作者**：Bockenhauer D, et al.
**摘要**：研究发现KCNJ10基因突变导致EAST综合征(癫痫、共济失调、感音神经性耳聋和肾小管病)，但未直接讨论抗体，提示KCNJ10功能缺陷与疾病关联，为后续抗体研究提供背景支持。
3. **文献名称**：*Expression and function of KCNJ10 in experimental autoimmune encephalomyelitis*
**作者**：Zhang Y, et al.
**摘要**：通过实验性自身免疫性脑脊髓炎(EAE)模型，发现KCNJ10在星形胶质细胞中的表达下调，并可能成为自身免疫攻击的靶点，间接提示抗KCNJ10抗体的潜在致病作用。
---
**备注**：KCNJ10抗体的直接研究相对较少，部分文献侧重于基因突变或通道功能。上述文献中，第1篇为抗体相关核心研究，其余提供关联背景。如需更多文献，建议通过PubMed等数据库以“KCNJ10 antibody”为关键词检索。
The KCNJ10 antibody targets the KCNJ10 protein, encoded by the KCNJ10 gene, which belongs to the inwardly rectifying potassium (Kir) channel family. Kir4.1. the protein product, plays a critical role in maintaining potassium ion homeostasis and regulating membrane potential, particularly in the brain, kidneys, and inner ear. In the central nervous system, Kir4.1 is predominantly expressed in astrocytes, where it supports neuronal excitability, potassium buffering, and extracellular space volume regulation. In the kidneys, it facilitates potassium recycling in distal nephrons, aiding electrolyte balance.
KCNJ10 dysfunction is linked to disorders like EAST/SeSAME syndrome (epilepsy, ataxia, sensorineural deafness, and tubulopathy) and neurodegenerative conditions. Autoantibodies against Kir4.1 have been implicated in autoimmune neuroinflammatory diseases, including multiple sclerosis and neuromyelitis optica spectrum disorders, suggesting its role as a potential biomarker.
The KCNJ10 antibody is widely used in research to study Kir4.1 expression patterns, localization, and pathological mechanisms via techniques like immunohistochemistry, Western blotting, and immunofluorescence. It also aids in diagnosing autoimmune conditions by detecting anti-Kir4.1 antibodies in patient sera. Understanding KCNJ10's biology and its antibodies provides insights into potassium channel-related diseases and therapeutic targeting.
×
