| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MST161; SLRR2A; MSTP161 |
| WB Predicted band size | 44 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PRELP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PRELP抗体的3篇文献摘要示例(文献信息为虚构示例，仅供格式参考)：
1. **文献名称**：*PRELP regulates collagen fibrillogenesis through interactions with glycosaminoglycans*
**作者**：Smith A, et al.
**摘要**：研究利用PRELP抗体探究PRELP蛋白在胶原纤维组装中的作用，发现其通过结合硫酸软骨素调控细胞外基质稳定性，影响组织机械性能。
2. **文献名称**：*Autoantibodies against PRELP in systemic sclerosis patients*
**作者**：Zhang L, et al.
**摘要**：通过ELISA和免疫印迹检测发现，系统性硬化症患者血清中存在PRELP自身抗体，提示其可能参与纤维化疾病中的自身免疫反应。
3. **文献名称**：*Development of a monoclonal PRELP antibody for cancer biomarker studies*
**作者**：Tanaka K, et al.
**摘要**：报道一种高特异性抗人PRELP单克隆抗体的开发，应用于免疫组化检测多种肿瘤组织中PRELP表达下调，提示其潜在抑癌作用。
(注：以上内容为模拟示例，实际文献需通过PubMed/Google Scholar等平台检索关键词如“PRELP antibody”或“PRELP protein function”获取。)
**Background of PRELP Antibody**
PRELP (Proline/Arginine-Rich End Leucine-Rich Repeat Protein) is a small leucine-rich repeat proteoglycan (SLRP) predominantly found in connective tissues, including cartilage, bone, and skin. It plays a critical role in maintaining extracellular matrix (ECM) stability by interacting with collagen fibrils and other ECM components through its leucine-rich repeat domains. PRELP’s N-terminal region, rich in proline and arginine, mediates binding to glycosaminoglycans and basement membrane components, contributing to tissue organization and mechanical resilience.
Research highlights PRELP’s involvement in regulating innate immunity and inflammation. It inhibits the complement system by binding to complement C1q, modulating immune responses in tissues. Dysregulation of PRELP is linked to pathologies like osteoarthritis, rheumatoid arthritis, and fibrosis, underscoring its role in ECM homeostasis and disease.
PRELP antibodies are essential tools for detecting and quantifying PRELP expression in tissues or biological fluids. They enable studies on PRELP’s localization, function, and interaction partners via techniques like immunohistochemistry, Western blotting, and ELISA. These antibodies also aid in exploring PRELP’s therapeutic potential, such as targeting ECM remodeling in degenerative diseases or modulating immune pathways. Commercial PRELP antibodies are typically validated for specificity across human, mouse, or rat samples, supporting translational research in connective tissue disorders and inflammation.
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