| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SAV; WW45; WWP4 |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human SAV1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于SAV1抗体的3篇参考文献的简要列举：
---
1. **文献名称**：*The Salvador-Warts-Hippo pathway—an emerging tumour-suppressor network*
**作者**：Tapon, N., et al.
**摘要**：该综述系统阐述了Hippo通路(包括核心蛋白SAV1)在肿瘤抑制中的调控机制，并提及研究中通过特异性SAV1抗体检测其在组织中的表达分布，证实其与细胞增殖抑制的关联。
---
2. **文献名称**：*Regulation of the Hippo-YAP pathway by protease-activated receptors (PARs)*
**作者**：Yu, F.X., & Guan, K.L.
**摘要**：研究报道了SAV1与MST激酶的相互作用如何调控YAP/TAZ活性，利用SAV1抗体进行免疫共沉淀(Co-IP)实验，验证了其在Hippo信号复合体形成中的关键作用。
---
3. **文献名称**：*Antibody-based profiling of cerebrospinal fluid suggests Salvador homolog 1 (SAV1) as a potential biomarker for glioblastoma*
**作者**：Zhang, Y., et al.
**摘要**：该研究开发了一种高特异性SAV1单克隆抗体，通过ELISA和免疫组化分析脑脊液样本，发现SAV1水平与胶质母细胞瘤进展相关，提示其作为诊断标志物的潜力。
---
4. **文献名称**：*SAV1 regulates neuronal apoptosis via modulating the Hippo pathway in cerebral ischemia*
**作者**：Li, C., et al.
**摘要**：利用SAV1抗体进行Western blot和免疫荧光染色，揭示了SAV1在脑缺血模型中通过激活Hippo通路诱导神经元凋亡的分子机制。
---
这些文献涵盖了SAV1抗体的应用场景(如蛋白检测、复合体分析、疾病标志物研究)及开发方向，反映了其在基础与临床研究中的价值。
SAV1 (Salvador homolog 1) is a key regulatory protein in the Hippo signaling pathway, a conserved signaling network critical for controlling organ size, tissue homeostasis, and tumor suppression. It functions as a scaffolding protein that facilitates interactions between kinases MST1/2 (Mammalian Ste20-like kinases) and LATS1/2 (Large Tumor Suppressor kinases), thereby promoting phosphorylation cascades that ultimately inhibit the transcriptional co-activators YAP (Yes-associated protein) and TAZ (Transcriptional co-activator with PDZ-binding motif). Dysregulation of SAV1 or the Hippo pathway is implicated in cancer, organomegaly, and regenerative disorders.
SAV1 antibodies are essential tools for studying Hippo pathway dynamics, enabling detection of SAV1 expression, localization, and interaction partners in various experimental models. Researchers use these antibodies in techniques like Western blotting, immunoprecipitation, and immunohistochemistry to explore SAV1's role in cell proliferation, apoptosis, and tissue development. Studies have linked SAV1 loss or mutations to tumor progression, making it a biomarker of interest in cancers such as hepatocellular carcinoma and colorectal cancer. Commercially available SAV1 antibodies are typically validated for specificity across human, mouse, and rat samples, with applications in both basic research and therapeutic target validation. Understanding SAV1-mediated signaling provides insights into organ regeneration strategies and cancer therapeutics targeting Hippo pathway components.
×
