| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 59 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human MAOB |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MAOB抗体的3篇代表性文献，格式为标题、作者及摘要概括：
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1. **"Selective Monoclonal Antibody Development for Human Monoamine Oxidase B (MAO-B)"**
*作者：Smith et al. (2018)*
**摘要**：研究团队开发了一种针对人源MAO-B的高特异性单克隆抗体，通过免疫印迹和免疫组化验证其灵敏度及与MAO-A的交叉反应性。该抗体成功用于检测帕金森病模型中的MAO-B表达变化。
2. **"MAO-B Antibody-Based Imaging Probes for Neurodegenerative Disease Diagnosis"**
*作者：Lee & Kim (2020)*
**摘要**：探索了MAO-B抗体与荧光标记结合的新型成像探针，用于活体脑部MAO-B活性可视化。实验表明该探针可区分阿尔茨海默病小鼠与对照组，提示其在神经退行性疾病早期诊断中的潜力。
3. **"Role of MAO-B in Glial Activation: Insights from Antibody-Mediated Inhibition Studies"**
*作者：Chen et al. (2019)*
**摘要**：利用MAO-B抗体阻断星形胶质细胞中的酶活性，发现MAO-B抑制可减少炎症因子释放，并改善神经炎症模型中的神经元存活率，为靶向MAO-B的抗炎治疗提供依据。
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**说明**：上述文献为示例性质，实际引用需核对真实论文信息。建议通过PubMed或Web of Science以“MAO-B antibody”“monoamine oxidase B immunoassay”等关键词检索最新研究。
Monoamine oxidase B (MAO-B) is a mitochondrial outer membrane enzyme that plays a key role in neurotransmitter metabolism by catalyzing the oxidative deamination of biogenic amines, including dopamine, phenethylamine, and trace amines. Primarily expressed in astrocytes, liver, and platelets, MAO-B is distinct from its isoform MAO-A in substrate preference and inhibitor sensitivity. MAO-B antibodies are essential tools in neuroscience and biomedical research, enabling the detection and localization of MAO-B protein in tissues or cells through techniques like Western blotting, immunohistochemistry, and immunofluorescence.
Elevated MAO-B activity has been linked to neurodegenerative disorders such as Parkinson’s disease and Alzheimer’s disease, where it may contribute to oxidative stress and neuronal damage via excessive dopamine degradation or toxic metabolite production. MAO-B antibodies help investigate these pathological mechanisms by assessing enzyme expression changes in disease models or postmortem tissues. Additionally, they are used in drug development studies targeting MAO-B inhibitors (e.g., selegiline, rasagiline), which are approved for Parkinson’s therapy to enhance dopamine availability. Beyond neurodegeneration, MAO-B antibodies aid in exploring roles in cancer, aging, and psychiatric conditions. Their specificity and reliability are critical for validating experimental findings and advancing therapeutic strategies.
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