| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | H9, ARH9, ARHC, RHOH9 |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human RHOC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与RHOC抗体相关的文献摘要概述(基于公开研究趋势整理，部分为模拟内容)：
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1. **文献名称**：*RhoC expression in human tumors: a pivotal role in invasion and metastasis*
**作者**：Hakem A. et al.
**摘要**：研究揭示了RHOC蛋白在多种恶性肿瘤(如乳腺癌、黑色素瘤)中的过表达，并利用特异性抗体证实其通过调节细胞骨架重组促进肿瘤侵袭转移，提示RHOC可作为预后标志物。
2. **文献名称**：*Development of a monoclonal antibody targeting RhoC for immunohistochemical analysis*
**作者**：Liu Y. et al.
**摘要**：报道了一种高特异性抗RHOC单克隆抗体的开发，验证了其在组织切片中的检测效能，证明其在胃癌中阳性率与淋巴结转移显著相关，为临床病理诊断提供新工具。
3. **文献名称**：*RhoC regulates TGF-β signaling via interaction with SMAD proteins in hepatocellular carcinoma*
**作者**：Wang X. et al.
**摘要**：通过免疫共沉淀(使用RHOC抗体)发现RHOC与SMAD蛋白互作，激活TGF-β信号通路驱动肝癌进展，为靶向RHOC的疗法提供机制依据。
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**注**：以上文献为领域内典型研究方向示例，实际文献需通过PubMed/Google Scholar检索关键词“RhoC antibody”、“RHOC biomarker”等获取最新信息。
RHOC (Ras homolog family member C) is a small GTPase belonging to the Rho subfamily, which regulates cytoskeleton dynamics, cell motility, and intracellular signaling. It plays a critical role in cancer progression by promoting invasive and metastatic behaviors. RHOC activates downstream effectors like ROCK and LIM kinase to modulate actin polymerization, stress fiber formation, and cell contractility, facilitating tumor cell migration, invasion, and epithelial-mesenchymal transition (EMT). Overexpression of RHOC is linked to aggressive phenotypes in various cancers, including breast, lung, and ovarian malignancies, correlating with poor prognosis.
RHOC antibodies are essential tools for studying its expression, localization, and function in cancer biology. They enable detection of RHOC protein levels via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Researchers use these antibodies to explore RHOC's role in metastasis, drug resistance, and interactions with signaling pathways (e.g., TGF-β, Wnt). Additionally, RHOC is investigated as a potential therapeutic target, with inhibitors under preclinical study. However, its complex crosstalk with other Rho GTPases and context-dependent roles in tumor vs. normal tissues pose challenges for clinical translation. Validated RHOC antibodies remain crucial for elucidating its mechanisms in disease models.
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