| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RABL; L1880; RAB5L; RAB5CL |
| WB Predicted band size | 23 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human RAB5C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RAB5C抗体的3篇示例参考文献(内容为模拟概括，仅供参考)：
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1. **文献名称**：*RAB5C regulates endosomal trafficking and EGFR signaling in cancer cells*
**作者**：Li, X. et al.
**摘要**：本研究利用RAB5C特异性抗体，通过免疫荧光和Western blot分析，揭示了RAB5C在调控肺癌细胞EGFR内吞及信号转导中的作用，发现其过表达促进肿瘤侵袭。
2. **文献名称**：*Role of RAB5C in viral entry pathways mediated by clathrin-independent endocytosis*
**作者**：Wang, Y. & Chen, Z.
**摘要**：通过抗体介导的RAB5C功能抑制实验，证明RAB5C参与多种病毒(如流感病毒)的非网格蛋白依赖内吞途径，为抗病毒治疗提供新靶点。
3. **文献名称**：*Altered RAB5C expression in neurodegenerative disorders correlates with lysosomal dysfunction*
**作者**：Smith, J. et al.
**摘要**：采用RAB5C抗体进行脑组织免疫组化分析，发现阿尔茨海默病患者神经元中RAB5C表达异常，导致内体-溶酶体运输缺陷，加剧病理蛋白累积。
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*注：上述文献为示例性概括，实际研究中建议通过PubMed、Web of Science等平台检索具体文献。若需真实文献，可提供论文数据库访问权限进一步筛选。*
The RAB5C antibody is a crucial tool in studying the RAB5C protein, a member of the Rab GTPase family involved in regulating intracellular membrane trafficking. RAB5C specifically controls early endosome dynamics, including vesicle formation, motility, and fusion, which are essential for endocytosis, signal transduction, and organelle biogenesis. Dysregulation of RAB5C is linked to diseases such as cancer and neurodegenerative disorders, making it a target for biomedical research.
The antibody enables detection and localization of RAB5C in cells or tissues via techniques like Western blotting, immunofluorescence, and immunohistochemistry. It helps elucidate RAB5C's role in cellular processes, including receptor internalization, autophagy, and pathogen invasion. Commercial RAB5C antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions), and validated for specificity using knockout controls.
Researchers also use RAB5C antibodies to explore its interaction with effectors (e.g., EEA1. Rabaptin-5) and its GTP/GDP cycling mechanism. In cancer studies, RAB5C overexpression is associated with metastasis, highlighting its potential as a therapeutic biomarker. Overall, this antibody serves as a vital reagent for dissecting membrane trafficking pathways and their implications in health and disease.
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