| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human RAB3C |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及RAB3C抗体的研究文献摘要信息：
1. **文献名称**：RAB3C regulates melanoma progression through extracellular vesicle secretion
**作者**：Chen Y, et al.
**摘要**：研究发现RAB3C通过调控外泌体分泌促进黑色素瘤转移，利用RAB3C抗体进行免疫印迹和免疫荧光实验，证实其与肿瘤细胞侵袭性相关。
2. **文献名称**：RAB3C interacts with exocyst components in synaptic vesicle trafficking
**作者**：Wang L, et al.
**摘要**：通过RAB3C抗体共沉淀实验，揭示RAB3C与exocyst复合物在神经突触囊泡运输中的相互作用机制，为突触传递研究提供新靶点。
3. **文献名称**：Dysregulation of RAB3C in pancreatic cancer correlates with poor prognosis
**作者**：Zhang H, et al.
**摘要**：采用RAB3C抗体对胰腺癌组织进行免疫组化分析，发现RAB3C高表达与患者生存期缩短显著相关，提示其作为潜在预后标志物的价值。
4. **文献名称**：RAB3C phosphorylation modulates lysosomal degradation in autophagy
**作者**：Kimura T, et al.
**摘要**：通过RAB3C特异性抗体阻断实验，证明RAB3C的磷酸化修饰影响自噬溶酶体通路，揭示其在细胞代谢调控中的新功能。
(注：以上为模拟文献案例，实际引用需核对真实数据库)
The RAB3C antibody is a tool used to detect and study RAB3C, a member of the RAB family of small GTPases involved in regulating intracellular vesicle trafficking. RAB3C, part of the RAB3 subfamily (alongside RAB3A, B, and D), plays a role in exocytosis, particularly in neurotransmitter release and secretory processes. While RAB3A is predominantly expressed in neurons and endocrine cells, RAB3C shows broader tissue distribution, including the brain, pancreas, and certain cancers. Its function involves cycling between GTP-bound (active) and GDP-bound (inactive) states to mediate vesicle docking, membrane fusion, and cargo release.
RAB3C antibodies are critical for investigating its expression patterns, subcellular localization, and interactions with effector proteins like RIM and Munc-13. These antibodies are typically raised in hosts such as rabbits or mice, targeting specific epitopes (e.g., N-terminal or C-terminal regions). Validated applications include Western blotting, immunofluorescence, and immunohistochemistry. Studies suggest RAB3C overexpression in cancers like melanoma or gastric cancer, linking it to tumor progression and metastasis, making it a potential biomarker or therapeutic target. Researchers also use RAB3C antibodies to explore its role in neurological disorders, diabetes, and secretory pathway dysregulation. Specificity validation is essential due to high homology among RAB3 isoforms.
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