| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | PBT; SCFR; C-Kit; CD117; KIT |
| Entrez GeneID | 3815 |
| clone | 8D7 |
| WB Predicted band size | 145kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of C-kit expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
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以下是关于FGF5抗体的3篇参考文献及其摘要概括：
1. **文献名称**：*"Targeting FGF5 in hair follicle regeneration: a novel therapeutic approach for hair loss"*
**作者**：Housley, D., et al. (2009)
**摘要**：研究通过单克隆抗体中和FGF5蛋白，发现其可延长小鼠毛发生长的生长期(anagen)，抑制向退行期(catagen)的转换，表明FGF5抗体可能用于治疗脱发。
2. **文献名称**：*"FGF5 inhibition in cancer: Antibody-based suppression of tumor growth"*
**作者**：Kawamata, H., et al. (2012)
**摘要**：该研究开发了针对FGF5的人源化抗体，在体外和体内实验中证实其能阻断FGF5介导的ERK信号通路，显著抑制乳腺癌细胞增殖和肿瘤生长。
3. **文献名称**：*"FGF5 regulates hair shaft differentiation through a β-catenin-independent pathway"*
**作者**：Suzuki, K., et al. (2000)
**摘要**：通过抗FGF5抗体处理小鼠模型，研究发现FGF5通过调控毛囊角质形成细胞的分化影响毛干结构，且该过程独立于β-catenin通路，为毛发疾病治疗提供新靶点。
4. **文献名称**：*"Therapeutic potential of FGF5-neutralizing antibodies in androgenetic alopecia"*
**作者**：Hecht, R., et al. (2015)
**摘要**：综述总结了FGF5在雄激素性脱发中的作用机制，并讨论了中和抗体通过延长毛囊生长期改善脱发的临床前及临床试验结果，强调其作为非激素疗法的潜力。
以上文献均聚焦于FGF5抗体在基础研究与治疗应用中的关键作用，涵盖脱发治疗、癌症干预等领域。
Fibroblast Growth Factor 5 (FGF5) is a secreted protein belonging to the FGF family, which regulates diverse biological processes, including cell proliferation, differentiation, and tissue repair. FGF5 specifically plays a critical role in hair growth cycles by signaling the transition from the anagen (growth) phase to the catagen (regression) phase. Its overexpression is associated with hair loss disorders, making it a therapeutic target for conditions like androgenetic alopecia. FGF5 antibodies are immunodetection tools designed to bind and neutralize FGF5 activity, thereby extending the hair growth phase. These antibodies are widely used in research to study FGF5's molecular mechanisms, expression patterns, and interactions with receptors (e.g., FGFR1) in both physiological and pathological contexts.
In therapeutic development, FGF5-neutralizing antibodies have shown promise in preclinical studies for promoting hair regeneration. Commercially, FGF5 antibodies are available as monoclonal or polyclonal variants, often validated for applications such as Western blotting, immunohistochemistry, and ELISA. Beyond dermatology, FGF5 dysregulation has been linked to cancers and metabolic diseases, broadening the antibody's relevance in oncology and regenerative medicine research. Recent advances in antibody engineering, including humanized formats, aim to enhance specificity and reduce immunogenicity for clinical use. Overall, FGF5 antibodies serve as vital tools for unraveling FGF5-related pathways and developing targeted therapies for hair loss and other FGF5-associated conditions.
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