Rabbit Polyclonal FGF8 Antibody

Fibroblast Growth Factor 8 (FGF8) is a secreted signaling protein belonging to the FGF family, which regulates key processes in embryonic development, including limb formation, brain patterning, and organogenesis. It binds to FGF receptors (FGFRs) to activate downstream pathways like MAPK and PI3K, influencing cell proliferation, migration, and differentiation. FGF8 antibodies are essential tools for detecting and studying the spatial-temporal expression, localization, and functional roles of FGF8 in developmental biology and disease models. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence. Research involving FGF8 antibodies has elucidated its involvement in disorders like congenital syndromes, neurodevelopmental defects, and cancers (e.g., breast and prostate). Commercially available FGF8 antibodies are typically generated against recombinant FGF8 proteins or specific epitopes, with validation in knockout controls to ensure specificity. Their application extends to both basic research and clinical studies, aiding in the exploration of FGF8's therapeutic potential or its role as a biomarker.