| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | KACL; PILAR; UNQ5792 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human CLEC2A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是假设的关于CLEC2A抗体的参考文献示例(非真实文献，仅供格式参考)：
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1. **Title**: *CLEC2A as a Novel Inhibitory Receptor on Human NK Cells*
**Authors**: Brown, A. et al.
**Summary**: 研究报道CLEC2A在自然杀伤(NK)细胞表面作为抑制性受体，其抗体阻断实验表明CLEC2A可调控NK细胞的细胞毒性及细胞因子分泌，提示其在抗肿瘤免疫中的潜在作用。
2. **Title**: *Targeting CLEC2A in Tumor-Associated Macrophages Modulates Immune Microenvironment*
**Authors**: Sato, Y. et al.
**Summary**: 通过开发CLEC2A特异性单克隆抗体，研究发现CLEC2A在肿瘤相关巨噬细胞(TAMs)中高表达，抗体介导的CLEC2A抑制可减少免疫抑制性细胞因子释放，增强抗肿瘤T细胞反应。
3. **Title**: *Structural Characterization of CLEC2A-Ligand Interaction Using Antibody-Based Probes*
**Authors**: Verdino, P. et al.
**Summary**: 利用CLEC2A抗体解析其与病毒糖蛋白的相互作用结构，揭示CLEC2A的糖类识别机制，为抗感染治疗提供新靶点。
4. **Title**: *CLEC2A Expression in Autoimmune Disorders: Diagnostic Implications*
**Authors**: Li, X. et al.
**Summary**: 通过CLEC2A抗体检测患者外周血单核细胞，发现CLEC2A在类风湿性关节炎中表达上调，提示其可作为疾病活动的生物标志物。
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注：以上文献为虚构示例，实际研究中请通过PubMed、Web of Science等平台检索真实发表的论文。
The CLEC2A (C-type lectin domain family 2 member A) antibody is a tool used to study the CLEC2A protein, a member of the C-type lectin-like receptor family. CLEC2A is primarily expressed on immune cells, including dendritic cells, natural killer (NK) cells, and certain T-cell subsets. It functions as a cell-surface receptor involved in immune regulation, though its exact ligands and signaling mechanisms remain less characterized compared to other CLEC family members. CLEC2A is thought to interact with ligands on neighboring cells or pathogens, potentially modulating immune responses such as cytokine production, cell adhesion, or cytotoxicity.
Research on CLEC2A antibodies focuses on elucidating its role in immune surveillance, infection, and cancer. For example, studies suggest CLEC2A may influence NK cell-mediated antitumor activity or dendritic cell maturation. Antibodies targeting CLEC2A are used in techniques like flow cytometry, immunohistochemistry, or functional assays to detect protein expression, block receptor-ligand interactions, or explore signaling pathways.
CLEC2A is structurally related to other immune receptors like NKp80 (CLEC2B), but its unique functions and contributions to diseases like autoimmune disorders or viral infections are still under investigation. Its potential as a therapeutic target or biomarker in immunotherapy strategies adds to the interest in developing specific antibodies. Current challenges include clarifying its ligand specificity and downstream signaling cascades, which are critical for understanding its physiological and pathological roles.
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