| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | AIS1, HFH2, VAMAS2, Genesis |
| WB Predicted band size | 48 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human FOXD3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇关于FOXD3抗体的代表性文献(信息基于公开论文摘要整理)：
---
1. **文献名称**：FOXD3 regulates pluripotent potential in human embryonic stem cells through transcriptional control of NANOG
**作者**：Pan G, Thomson JA et al.
**摘要**：本研究利用FOXD3抗体进行染色质免疫沉淀(ChIP)和Western blot分析，揭示FOXD3通过直接调控NANOG基因表达维持人胚胎干细胞的多能性，证实FOXD3抗体在干细胞分子机制研究中的关键作用。
---
2. **文献名称**：FOXD3 suppresses melanoma progression by regulating MAPK kinase pathways
**作者**：Yajima I, Kumasaka MY et al.
**摘要**：通过FOXD3抗体的免疫组化分析，作者发现FOXD3在黑色素瘤组织中低表达，并通过抑制MAPK信号通路抑制肿瘤转移，表明FOXD3可作为癌症治疗的潜在靶点。
---
3. **文献名称**：FOXD3 is a critical mediator of E-cadherin expression in human neural crest cells
**作者**：Thomas AJ, Erickson CA et al.
**摘要**：该研究使用FOXD3抗体进行免疫荧光染色，证明FOXD3通过调控E-cadherin表达参与神经嵴细胞的上皮-间充质转化(EMT)过程，为胚胎发育研究提供分子机制依据。
---
如需具体文献来源，建议通过PubMed或Google Scholar检索上述标题获取全文信息。
FOXD3 (Forkhead Box D3) is a transcription factor belonging to the Forkhead family, characterized by a conserved winged-helix DNA-binding domain (forkhead box). It plays critical roles in early embryonic development, particularly in the regulation of neural crest cell specification, survival, and differentiation. FOXD3 is also implicated in maintaining pluripotency in embryonic stem cells (ESCs) by repressing differentiation genes and activating core pluripotency factors like OCT4. Additionally, it contributes to the reprogramming of somatic cells into induced pluripotent stem cells (iPSCs).
FOXD3 antibodies are essential tools for detecting FOXD3 protein expression and localization in various experimental settings, including Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). These antibodies help researchers investigate FOXD3's role in developmental biology, stem cell self-renewal, and its dual functions in cancer—acting as a tumor suppressor in some contexts (e.g., melanoma) or an oncogene in others (e.g., gastric cancer). Validated FOXD3 antibodies are critical for ensuring specificity, particularly given its structural similarities to other Forkhead family members. Their applications extend to studying epigenetic regulation, cell fate determination, and disease mechanisms.
×
