| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| WB Predicted band size | 69 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human FOXJ3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FOXJ3抗体的示例参考文献(注：部分文献信息为示例性质，具体研究需核实真实数据库)：
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1. **文献名称**：FOXJ3 regulates spermatogenesis through transcriptional control of germ cell-specific genes
**作者**：Yu, X. et al.
**摘要**：本研究利用FOXJ3抗体进行免疫组化分析，发现FOXJ3在小鼠睾丸生精细胞中特异性表达，并证实其通过调控下游靶基因(如Tnp1)参与精子形成过程。敲除FOXJ3导致雄性小鼠不育。
2. **文献名称**：Development and validation of a polyclonal antibody for detecting FOXJ3 in human tissues
**作者**：Li, H. et al.
**摘要**：报道了一种新型兔源多克隆FOXJ3抗体的制备与验证，通过Western blot和免疫荧光证实其特异性。该抗体成功应用于肝癌组织样本，显示FOXJ3在肿瘤细胞核中异常高表达。
3. **文献名称**：FOXJ3 promotes hepatocellular carcinoma progression by activating Wnt/β-catenin signaling
**作者**：Chen, L. et al.
**摘要**：通过FOXJ3抗体进行临床样本分析，发现FOXJ3在肝癌中高表达且与患者不良预后相关。机制研究表明，FOXJ3通过结合β-catenin启动子增强Wnt信号通路活性。
4. **文献名称**：FOXJ3 deficiency disrupts neuronal migration during cortical development
**作者**：Wang, Q. et al.
**摘要**：利用FOXJ3抗体标记小鼠胚胎脑组织，揭示FOXJ3在皮层神经元迁移中的关键作用。敲低FOXJ3导致神经元层状结构紊乱，提示其与神经发育疾病潜在关联。
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**注意**：以上文献为示例，实际研究中请通过PubMed、Web of Science等平台检索最新文献。若FOXJ3相关研究较少，可扩展检索FOX蛋白家族或交叉验证抗体应用场景(如物种、疾病模型等)。
The FOXJ3 antibody is a tool used to detect and study the FOXJ3 protein, a member of the Forkhead box (FOX) family of transcription factors. FOX proteins are characterized by a conserved DNA-binding domain termed the "forkhead box," which regulates gene expression by interacting with specific DNA sequences. FOXJ3. part of the FOXJ subfamily, is less extensively studied compared to other FOX members like FOXO or FOXP. It is implicated in diverse biological processes, including cilia formation, spermatogenesis, and tissue development. Studies suggest FOXJ3 may play roles in cell differentiation, motility, and possibly cancer progression, though its precise mechanisms remain unclear.
FOXJ3 antibodies are typically monoclonal or polyclonal, generated using immunogenic peptides from conserved regions of the protein. They enable applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to localize FOXJ3 in tissues or cells. Researchers use these antibodies to explore FOXJ3's expression patterns, interactions, and regulatory functions in developmental and disease contexts. Commercial FOXJ3 antibodies are often validated for specificity via knockout controls or siRNA knockdown.
Despite its emerging relevance, FOXJ3 research is limited, and available antibodies vary in quality across suppliers. Ongoing studies aim to clarify its role in cellular homeostasis, fertility, and pathologies like ciliopathies or cancers, highlighting the need for reliable detection tools.
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