| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HTLF |
| WB Predicted band size | 47 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human FOXN2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于FOXN2抗体的参考文献示例(注：以下内容为虚构示例，实际文献需通过学术数据库检索)：
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1. **文献名称**: "FOXN2 Expression in Non-Small Cell Lung Cancer and Its Prognostic Implications"
**作者**: Zhang L, et al.
**摘要**: 本研究通过免疫组化(IHC)使用FOXN2特异性抗体，发现FOXN2在肺癌组织中高表达，且与患者生存率降低显著相关，提示其可能作为肺癌预后的生物标志物。
2. **文献名称**: "FOXN2 Regulates Neural Stem Cell Differentiation via Wnt Signaling"
**作者**: Li X, Wang Y, et al.
**摘要**: 利用FOXN2抗体进行Western blot和免疫荧光分析，证实FOXN2通过激活Wnt/β-catenin通路调控神经干细胞向神经元分化，为神经系统疾病治疗提供新靶点。
3. **文献名称**: "Epigenetic Role of FOXN2 in Hepatocellular Carcinoma Progression"
**作者**: Chen H, et al.
**摘要**: 通过染色质免疫沉淀(ChIP)结合FOXN2抗体，发现FOXN2与肝癌相关基因的启动子区域结合，调控表观遗传修饰，促进肿瘤侵袭转移。
4. **文献名称**: "FOXN2 Antibody Validation for Flow Cytometry in T-cell Studies"
**作者**: Smith J, et al.
**摘要**: 本研究系统验证了FOXN2抗体在流式细胞术中的特异性，证明其在检测T细胞亚群中FOXN2蛋白表达的可靠性，为免疫学研究提供工具支持。
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**建议**：实际研究中，可通过PubMed、Google Scholar等平台以关键词“FOXN2 antibody”、“FOXN2 immunohistochemistry”等检索最新文献，并优先选择经过抗体验证的高质量论文(如发表于《Nature》、《Cell》子刊或专业抗体数据库CiteAb推荐的文献)。
FOXN2 (Forkhead Box N2) is a member of the forkhead box (FOX) family of transcription factors, characterized by a conserved DNA-binding domain termed the "forkhead" or "winged-helix" domain. Initially identified for its role in developmental processes, FOXN2 is implicated in regulating gene expression involved in cell differentiation, proliferation, and apoptosis. It shares structural homology with FOXN1. a critical regulator of thymic epithelial development and T-cell maturation, but exhibits distinct expression patterns and functions. FOXN2 is broadly expressed in tissues, including the brain, liver, and reproductive organs, and has been linked to neurodevelopment, epithelial cell differentiation, and tissue homeostasis.
Research highlights FOXN2's dual role in cancer, acting as either a tumor suppressor or oncogene depending on context. Studies report its downregulation in hepatocellular carcinoma, lung cancer, and gliomas, where it suppresses tumor growth by modulating cell cycle progression or apoptosis-related pathways. Conversely, FOXN2 overexpression in certain malignancies, such as breast cancer, correlates with poor prognosis, suggesting context-dependent functionality. FOXN2 antibodies are essential tools for investigating these mechanisms, enabling detection of protein expression, localization (nuclear/cytoplasmic), and interaction partners via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. Commercial antibodies are typically validated for specificity against the conserved forkhead domain or unique epitopes. Current research focuses on FOXN2's regulatory networks, post-translational modifications, and potential as a therapeutic target or biomarker, underscoring its emerging significance in cancer biology and regenerative medicine.
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