| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | BPES, PFRK, POF3, BPES1, PINTO |
| WB Predicted band size | 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human FOXL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于FOXL2抗体的参考文献(示例为模拟生成内容，实际文献需通过数据库核实)：
1. **《FOXL2 is a novel diagnostic marker for sex cord-stromal tumors》**
*作者：Cocquet J, et al.*
摘要：该研究验证了FOXL2抗体在鉴别卵巢颗粒细胞瘤中的特异性，通过免疫组化证实FOXL2蛋白在肿瘤组织中的高表达，并强调其作为分子标志物的临床应用价值。
2. **《Characterization of a polyclonal antibody against human FOXL2 protein》**
*作者：Uda M, et al.*
摘要：研究团队利用重组FOXL2蛋白制备兔多克隆抗体，经Western blot和免疫荧光验证其特异性，成功应用于检测小鼠和人类卵巢组织中的FOXL2表达定位。
3. **《FOXL2 mutations and ovarian function: Insights from antibody-based protein analysis》**
*作者：Pannetier M, et al.*
摘要：通过FOXL2抗体分析突变体蛋白的亚细胞分布，发现特定突变导致核定位异常，为解释卵巢早衰及性发育障碍提供了分子机制证据。
提示：建议通过PubMed或Google Scholar以“FOXL2 antibody”为关键词检索最新文献，并优先选择高被引研究或权威期刊(如*Endocrinology*、*Human Molecular Genetics*等)。
The FOXL2 antibody is a crucial tool in studying the FOXL2 protein, a transcription factor encoded by the *FOXL2* gene located on chromosome 3q22.3. FOXL2 plays a pivotal role in ovarian development, follicle maturation, and maintenance of ovarian function throughout reproductive life. Mutations in *FOXL2* are linked to blepharophimosis-ptosis-epicanthus inversus syndrome (BPES), characterized by eyelid malformations and, in some cases, premature ovarian insufficiency. Additionally, a somatic *FOXL2* mutation (c.402C>G) is a hallmark of adult-type granulosa cell tumors (AGCTs), making FOXL2 a diagnostic marker for these malignancies.
FOXL2 antibodies are widely used in research and diagnostics to detect FOXL2 expression via techniques like immunohistochemistry (IHC), Western blotting, or immunofluorescence. In research, these antibodies help elucidate FOXL2's regulatory roles in ovarian biology, steroidogenesis, and cell cycle control. Clinically, FOXL2 IHC aids in distinguishing AGCTs from other ovarian tumors, improving pathological accuracy. The antibody's specificity for FOXL2 ensures reliable identification of its nuclear localization, critical for validating its functional or pathogenic roles. However, antibody validation is essential, as cross-reactivity or batch variability can affect results. Overall, FOXL2 antibodies remain indispensable for advancing reproductive biology and gynecologic cancer research.
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