Rabbit Polyclonal FOXL1 Antibody

The FOXL1 antibody is a crucial tool in studying the FOXL1 protein, a member of the Forkhead box (FOX) family of transcription factors. FOXL1 is primarily expressed in mesenchymal cells, particularly in the gastrointestinal tract, where it regulates epithelial-mesenchymal interactions critical for maintaining tissue homeostasis. It plays a role in cell differentiation, proliferation, and organ development, with emerging links to pathologies like fibrosis and cancer. Researchers utilize FOXL1 antibodies to detect and quantify FOXL1 expression in tissues or cell lines via techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes within the FOXL1 protein. Validation often includes knockout controls or siRNA knockdown to confirm specificity. FOXL1 antibodies have been instrumental in elucidating its role in Wnt/β-catenin signaling modulation and stromal cell function. Their application extends to disease models, such as colorectal cancer studies, where FOXL1-expressing fibroblasts influence tumor microenvironments. As FOXL1's regulatory mechanisms remain incompletely understood, high-quality antibodies remain vital for advancing research in developmental biology and stromal biology.