| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MFH; QRF1; 12CC4; hFKH1B; HSPC215 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human FOXP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于FOXP1抗体的代表性文献摘要(虚构示例，仅供格式参考)：
1. **"FOXP1 regulates B-cell development by controlling PI3K signaling"**
*作者：Hu H et al. (2015)*
摘要：本研究利用FOXP1特异性抗体，通过流式细胞术和Western blot技术，发现FOXP1通过调控PI3K-AKT通路影响B细胞分化，Foxp1基因敲除小鼠显示B细胞发育阻滞。
2. **"FOXP1 expression correlates with prognosis in diffuse large B-cell lymphoma"**
*作者：Barrans S et al. (2018)*
摘要：通过免疫组化分析200例DLBCL样本中FOXP1蛋白表达，发现高表达FOXP1与患者总生存期缩短显著相关，提示其作为预后生物标志物的潜力。
3. **"FOXP1 antibody validation for lung development studies"**
*作者：Shu W et al. (2010)*
摘要：系统验证了FOXP1抗体在小鼠肺组织中的特异性，发现FOXP1在胚胎期肺上皮细胞中高表达，并通过ChIP-seq揭示其调控关键呼吸基因的分子机制。
4. **"FOXP1 as a marker for regulatory T cell subsets"**
*作者：Marson A et al. (2021)*
摘要：利用流式细胞术结合FOXP1抗体，鉴定出肠道中具有免疫抑制功能的FOXP1+ Treg细胞亚群，其功能缺失与自身免疫疾病发生相关。
(注：以上文献为示例性质，实际引用请通过PubMed/Google Scholar检索真实文献。)
The FOXP1 antibody is a crucial tool in studying the FOXP1 protein, a member of the Forkhead box (FOX) transcription factor family. FOXP1 plays vital roles in embryonic development, immune regulation, and tissue differentiation, particularly in the brain, heart, and lungs. It acts as a transcriptional repressor, modulating gene expression by binding to DNA. Dysregulation of FOXP1 is linked to developmental disorders, intellectual disabilities, and cancers, including lymphomas and solid tumors.
FOXP1 antibodies are widely used in research to detect and quantify FOXP1 expression via techniques like immunohistochemistry (IHC), Western blotting, and flow cytometry. In cancer studies, these antibodies help assess FOXP1's role as an oncogene or tumor suppressor, depending on context. For example, FOXP1 overexpression in diffuse large B-cell lymphoma correlates with poor prognosis, while its loss in some carcinomas may drive metastasis.
Clinically, FOXP1 antibodies aid in diagnosing B-cell malignancies, where FOXP1 expression helps differentiate subtypes. They also contribute to understanding FOXP1's interaction with other proteins (e.g., FOXP2/FOXP3) in immune pathways. Challenges include cross-reactivity with related FOX proteins, necessitating rigorous validation. Ongoing research explores FOXP1-targeted therapies, emphasizing the antibody's continued importance in translational medicine.
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