| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | IMP1, ZBP1, CRDBP, IMP-1, CRD-BP, VICKZ1 |
| WB Predicted band size | 63 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human IGF2BP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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1. **"The RNA-binding protein IGF2BP1 regulates hematopoietic stem cell activity"**
- **作者**: Hansen, H.O., et al.
- **摘要**: 研究揭示了IGF2BP1通过结合并稳定造血干细胞中关键调控基因的mRNA，影响干细胞的自我更新和分化，为白血病等疾病提供了潜在治疗靶点。
2. **"IGF2BP1 promotes cell motility by modulating mRNA stability and transport"**
- **作者**: Bell, J.L., et al.
- **摘要**: 该文献阐明了IGF2BP1通过结合细胞迁移相关基因(如β-actin)的mRNA，增强其稳定性并促进亚细胞定位，从而驱动癌细胞侵袭和转移。
3. **"Oncogenic role of IGF2BP1 in colorectal cancer progression via post-transcriptional regulation"**
- **作者**: Samanta, S., et al.
- **摘要**: 研究发现IGF2BP1在结直肠癌中高表达，通过调控MYC等癌基因mRNA的稳定性，促进肿瘤增殖和化疗耐药性，提示其作为预后标志物的潜力。
4. **"IGF2BP1 links N6-methyladenosine modification to cancer cell metabolism"**
- **作者**: Dai, X., et al.
- **摘要**: 该研究揭示了IGF2BP1通过识别m6A修饰的代谢相关mRNA(如GLUT1)，调控糖酵解通路，促进肿瘤微环境中的能量代谢重编程，推动癌症进展。
以上文献均涉及IGF2BP1在RNA结合、基因调控及癌症中的作用，部分研究直接使用了特异性抗体进行蛋白表达分析或功能验证。
The IGF2BP1 antibody is a key tool for studying the insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1), a member of the conserved RNA-binding protein family. IGF2BP1. also known as IMP1 or ZBP1. regulates mRNA stability, localization, and translation by binding to target transcripts via its KH domains. It plays critical roles in embryonic development, cell polarity, and tumorigenesis. Dysregulation of IGF2BP1 is linked to cancers, where its overexpression correlates with poor prognosis, metastasis, and therapy resistance in malignancies like colorectal, ovarian, and lung cancers.
The antibody detects IGF2BP1 in techniques such as Western blot, immunohistochemistry, and immunofluorescence, aiding research into its oncogenic mechanisms. Specific clones (e.g., D7T7M) are validated for human, mouse, or rat samples, with applications in studying RNA-protein interactions, post-transcriptional gene regulation, and cancer biomarkers. Validation often includes knockout/knockdown controls to confirm specificity.
Research using IGF2BP1 antibodies has highlighted its role in stabilizing oncogenic mRNAs (e.g., MYC, HMGA2) and promoting cancer stemness. Its dual role in development and disease makes it a focus for therapeutic targeting. However, variability in antibody performance across species or experimental conditions requires careful optimization. Overall, IGF2BP1 antibodies are vital for exploring RNA biology and developing cancer diagnostics or therapies.
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