| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | MLSN1, CSNB1C, LTRPC1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human TRPM1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TRPM1抗体的3篇参考文献示例(内容基于真实研究领域，但文献信息为模拟概括)：
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1. **文献名称**: *TRPM1 is a component of the retinal ON bipolar cell transduction channel*
**作者**: Koike C., et al.
**摘要**: 该研究通过免疫组织化学和Western blot技术，利用TRPM1特异性抗体揭示了其在视网膜ON双极细胞中的关键作用，证实TRPM1作为信号传导通道蛋白参与视觉信号传递。
2. **文献名称**: *TRPM1 mutations are associated with congenital stationary night blindness in humans*
**作者**: Bellone R.R., et al.
**摘要**: 研究者使用TRPM1抗体对患者视网膜组织进行染色，发现TRPM1基因突变导致蛋白表达缺失，从而引发先天性静止性夜盲症，证明了TRPM1在视觉通路中的必要性。
3. **文献名称**: *TRPM1 expression and function in melanoma progression*
**作者**: Oancea E., et al.
**摘要**: 通过抗TRPM1抗体进行免疫检测，该研究发现黑色素瘤中TRPM1的表达下调与肿瘤转移相关，提示其作为潜在治疗靶点或预后标志物的可能性。
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**注**：以上文献信息为示例性质，实际引用时请核对真实文献的标题、作者及内容。建议通过PubMed或Web of Science以关键词“TRPM1 antibody”或“TRPM1 function”检索最新研究。
TRPM1 (Transient Receptor Potential Melastatin 1) is a calcium-permeable ion channel belonging to the TRP superfamily, primarily expressed in melanocytes, retinal bipolar cells, and melanoma cells. It plays critical roles in melanin synthesis, retinal signaling, and cellular responses to environmental stimuli. TRPM1 dysfunction is linked to congenital stationary night blindness (CSNB) due to its role in ON-bipolar cell depolarization, as well as melanoma progression, where its expression often inversely correlates with tumor aggressiveness.
TRPM1 antibodies are immunological tools designed to detect and study this protein in research and diagnostic contexts. These antibodies are widely used in techniques like immunohistochemistry (IHC), Western blotting, and immunofluorescence to map TRPM1 expression patterns in tissues, investigate its regulation in melanoma, and explore its pathophysiology in ocular disorders. Commercially available antibodies typically target specific epitopes in the intracellular N-terminal or C-terminal regions of TRPM1. though validation remains essential due to occasional cross-reactivity with other TRP channels.
In clinical diagnostics, TRPM1 antibodies aid in differentiating melanoma subtypes and assessing metastatic potential. Recent studies also explore their potential in developing targeted therapies. However, challenges persist in standardizing detection protocols, as TRPM1 exhibits complex post-translational modifications and tissue-specific splice variants. Ongoing research continues to refine antibody specificity and expand applications in both basic science and translational medicine.
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