| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/5000 | Human,Mouse,Rat |
| Aliases | HOX1, HOX1D |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human HOXA4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于HOXA4抗体的参考文献示例(注：以下内容为示例性概括，实际文献需通过学术数据库核实)：
1. **文献名称**: *HOXA4 expression in human gliomas and its role in tumor cell proliferation*
**作者**: Smith J, et al.
**摘要**: 研究利用HOXA4抗体通过免疫组化分析HOXA4在神经胶质瘤中的表达水平，发现其高表达与肿瘤细胞增殖相关，提示HOXA4可能作为胶质瘤治疗的潜在靶点。
2. **文献名称**: *HOXA4 regulates hematopoietic stem cell differentiation via Wnt signaling*
**作者**: Lee S, et al.
**摘要**: 通过Western blot和免疫荧光技术(使用HOXA4抗体)，证实HOXA4通过调控Wnt通路影响造血干细胞分化，为血液系统疾病机制研究提供依据。
3. **文献名称**: *Developmental role of HOXA4 in vertebrate limb patterning*
**作者**: Garcia R, et al.
**摘要**: 在小鼠胚胎模型中，利用HOXA4抗体进行原位杂交和免疫染色，发现HOXA4在肢体发育中具有空间特异性表达，参与骨骼形成的调控。
4. **文献名称**: *HOXA4 antibody validation for clinical immunohistochemistry applications*
**作者**: Patel K, et al.
**摘要**: 研究系统评估了多种HOXA4抗体的特异性及敏感性，筛选出适用于临床组织样本检测的可靠抗体，并优化了染色条件。
建议通过PubMed、Web of Science等平台以“HOXA4 antibody”为关键词检索最新文献，并核实抗体应用的具体场景(如物种、实验方法)。
The HOXA4 antibody is a crucial tool for studying the HOXA4 protein, encoded by the HOXA4 gene within the Homeobox (HOX) gene family. HOX genes, highly conserved across species, regulate embryonic development, particularly axial patterning and organogenesis. HOXA4. located in the HOXA cluster on chromosome 7. plays roles in defining segmental identity along the anterior-posterior axis, influencing the development of the hindbrain, spinal cord, and organs like the lungs and gastrointestinal tract. Dysregulation of HOXA4 has been implicated in developmental disorders and cancers, including colorectal and esophageal malignancies.
HOXA4 antibodies enable detection and localization of the HOXA4 protein in tissues or cells via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies are essential for investigating HOXA4's expression patterns, interactions, and regulatory mechanisms. Researchers utilize them to explore HOXA4's role in stem cell differentiation, tissue regeneration, and disease progression. Specificity and validation (e.g., knockout controls) are critical when selecting HOXA4 antibodies, as cross-reactivity with other HOX proteins may occur. Both monoclonal and polyclonal variants are available, each offering distinct advantages in sensitivity and application flexibility. Overall, HOXA4 antibodies are vital for advancing studies in developmental biology, oncology, and regenerative medicine.
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