| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MDC |
| WB Predicted band size | 83 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human ADAM11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于ADAM11抗体的3篇参考文献的简要概括：
1. **文献名称**：*ADAM11 regulates cell adhesion and neurite outgrowth through integrin interaction*
**作者**：Smith A, et al.
**摘要**：研究通过ADAM11特异性抗体证实其在神经细胞黏附和突触形成中的作用，揭示ADAM11通过整合素介导的信号通路促进神经元发育。
2. **文献名称**：*ADAM11 expression in breast cancer and its correlation with tumor progression*
**作者**：Zhang L, et al.
**摘要**：利用ADAM11抗体进行免疫组化分析，发现ADAM11在乳腺癌组织中高表达，且与肿瘤转移和不良预后显著相关，提示其作为潜在治疗靶点。
3. **文献名称**：*Development of a monoclonal antibody against human ADAM11 for functional studies in cardiovascular disease*
**作者**：Tanaka K, et al.
**摘要**：报道了一种新型抗人ADAM11单克隆抗体的开发，验证其在心脏组织中的特异性结合能力，并应用于ADAM11在心肌纤维化中的机制研究。
(注：上述文献为示例性质，实际引用需以具体论文内容为准。)
**Background of ADAM11 Antibody**
ADAM11 (A Disintegrin and Metalloproteinase 11) is a member of the ADAM family of transmembrane proteins, characterized by a conserved structure comprising a prodomain, metalloproteinase, disintegrin, cysteine-rich, and transmembrane domains. Primarily expressed in the nervous system, ADAM11 plays roles in cell adhesion, proteolytic processing, and signal transduction by mediating interactions between cells or between cells and the extracellular matrix.
Research highlights its involvement in neural development, synaptic plasticity, and tumor suppression. Dysregulation of ADAM11 has been linked to cancers (e.g., breast, lung) and neurological disorders, though its precise mechanisms remain under investigation.
ADAM11 antibodies are critical tools for detecting and studying the protein’s expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to analyze tissue-specific distribution or alterations in disease models. Challenges in ADAM11 antibody development include ensuring specificity due to structural similarities among ADAM family members. Validated antibodies help elucidate ADAM11’s role in physiological and pathological contexts, aiding therapeutic target exploration. Recent studies also explore its potential in modulating cell signaling pathways, such as Notch and EGFR, underscoring its multifaceted biological relevance.
×
