| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/100-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | AC1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human ADCY1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ADCY1抗体的参考文献示例(注：以下内容为示例，非真实文献)：
1. **"Adenylyl Cyclase 1 (ADCY1) Antibody Localization in Murine Olfactory Sensory Neurons"**
*Author: Zhang et al.*
**摘要**：本研究利用ADCY1特异性抗体，通过免疫组化技术揭示了ADCY1在小鼠嗅觉感觉神经元中的高表达，证实其在嗅觉信号转导中的关键作用。
2. **"Validation of a Novel ADCY1 Monoclonal Antibody for Western Blot and Immunoprecipitation"**
*Author: Müller et al.*
**摘要**：文章报道了一种新型ADCY1单克隆抗体的开发与验证，证明其在Western blot和免疫沉淀实验中的高特异性，适用于检测多种物种的ADCY1蛋白表达。
3. **"ADCY1 Dysregulation in Hippocampal Neurons: Implications for Memory Deficits"**
*Author: Tanaka et al.*
**摘要**：通过ADCY1抗体的免疫荧光染色，研究发现阿尔茨海默病模型小鼠海马区ADCY1表达显著下调，提示其与记忆功能障碍的相关性。
4. **"ADCY1 Antibody-Based Profiling in Human Cardiomyopathy"**
*Author: Gupta et al.*
**摘要**：利用ADCY1抗体对心肌病患者组织样本进行Western blot分析，发现ADCY1蛋白水平异常升高，可能参与病理性心脏肥厚信号通路。
(如需真实文献，建议通过PubMed或Google Scholar检索关键词“ADCY1 antibody application”或“ADCY1 antibody validation”获取具体研究。)
The ADCY1 antibody is a crucial tool in biomedical research, targeting adenylate cyclase 1 (ADCY1), a membrane-bound enzyme that catalyzes the conversion of ATP to cyclic AMP (cAMP). ADCY1 belongs to the adenylate cyclase family, which plays a central role in intracellular signaling by regulating cAMP levels, a secondary messenger involved in diverse physiological processes. Primarily expressed in the brain, particularly in neurons, ADCY1 is implicated in synaptic plasticity, memory formation, and neurotransmitter signaling. It is also found in other tissues, including cardiac and smooth muscle cells, where it modulates cardiovascular functions.
The ADCY1 antibody enables researchers to detect and quantify ADCY1 protein expression, assess its cellular localization, and study its regulatory mechanisms. It is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate ADCY1's role in health and disease. Dysregulation of ADCY1 has been linked to neurological disorders, such as Alzheimer's disease, and cardiovascular conditions. Additionally, this antibody aids in exploring ADCY1's interaction with G-protein-coupled receptors (GPCRs) and its response to hormonal or pharmacological stimuli.
By facilitating ADCY1-specific research, this antibody contributes to understanding cAMP-mediated pathways and developing targeted therapies for related pathologies. Validation of its specificity and sensitivity ensures reliable experimental outcomes in both basic and translational studies.
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