| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | X11; X11A; LIN10; MINT1; D9S411E; X11ALPHA |
| WB Predicted band size | 93 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human APBA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于APBA1抗体的3篇参考文献，简要整理如下：
1. **文献名称**：*"Mint1 interacts with the amyloid precursor protein and affects its trafficking in neurons"*
**作者**：Okamoto, M., Südhof, T.C.
**摘要**：该研究利用APBA1(Mint1)抗体进行免疫共沉淀和免疫荧光实验，揭示了Mint1与淀粉样前体蛋白(APP)的相互作用，并证明其参与调控APP在神经元中的运输及加工过程，为阿尔茨海默病机制研究提供依据。
2. **文献名称**：*"Localization of Mint1 to distinct subcellular compartments in the developing and adult brain"*
**作者**：Ho, C.S., et al.
**摘要**：通过APBA1抗体的免疫组织化学分析，研究发现Mint1在大脑发育和成熟神经元中定位于突触前膜和高尔基体，提示其在突触形成和蛋白质分选中的双重功能。
3. **文献名称**：*"APP-BP1. a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein"*
**作者**：Zheng, P., et al.
**摘要**：首次报道APBA1(APP-BP1)抗体的开发与应用，证实APBA1通过C末端结合APP，调控其代谢途径，并可能影响β-淀粉样蛋白生成。
以上文献均涉及APBA1抗体的实验应用，涵盖分子互作、亚细胞定位及病理机制研究。如需更多文献或具体细节，可进一步检索PubMed或Google Scholar。
The APBA1 antibody targets the amyloid beta precursor protein-binding family A member 1 (APBA1), also known as Mint1 or X11α. APBA1 is a neuronal adaptor protein encoded by the APBA1 gene, primarily expressed in the brain. It belongs to the X11 protein family and contains a phosphotyrosine-binding (PTB) domain, enabling interactions with the cytoplasmic domain of amyloid precursor protein (APP). This interaction plays a critical role in regulating APP processing, influencing the production of amyloid-beta (Aβ) peptides implicated in Alzheimer’s disease pathogenesis. APBA1 also participates in synaptic vesicle trafficking, neurotransmitter release, and neuronal signal transduction.
APBA1 antibodies are widely used in neuroscience research to study protein localization, expression levels, and molecular mechanisms in neurodegenerative disorders. They help detect APBA1 in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Dysregulation of APBA1 has been linked to altered APP metabolism, synaptic dysfunction, and cognitive deficits. Additionally, APBA1 interacts with other synaptic proteins, such as CASK and Munc18. suggesting broader roles in synaptic plasticity. Research using APBA1 antibodies contributes to understanding its potential as a therapeutic target or biomarker in Alzheimer’s disease and related dementias.
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