| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PCB |
| WB Predicted band size | 130 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human PC |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于PRKCG(蛋白激酶C γ型)抗体的代表性文献，内容涵盖其临床意义及研究进展：
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1. **文献名称**：*Antibodies to protein kinase C gamma in paraneoplastic cerebellar degeneration*
**作者**：Shams'ili S, et al.
**摘要**：该研究首次报道PRKCG抗体与副肿瘤性小脑变性(PCD)的关联，发现部分肺癌或卵巢癌患者体内存在此抗体，提示其可能通过免疫攻击小脑神经元中的PKCγ蛋白导致共济失调。
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2. **文献名称**：*Autoantibodies against protein kinase C gamma in patients with cerebellar ataxia*
**作者**：Tanaka M, et al.
**摘要**：研究发现，非副肿瘤性自身免疫性小脑共济失调患者血清中可检测到PRKCG抗体，提示该抗体可能是此类疾病的潜在生物标志物，且与神经细胞凋亡机制相关。
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3. **文献名称**：*PKCγ autoantibodies in a Spanish cohort of neurological syndromes*
**作者**：Honnorat J, et al.
**摘要**：通过分析西班牙神经疾病患者队列，发现PRKCG抗体在罕见的小脑综合征患者中特异性表达，并强调其诊断价值及与特定肿瘤(如霍奇金淋巴瘤)的潜在关联。
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4. **文献名称**：*Protein kinase C gamma mutations and anti-PKCγ antibodies in spinocerebellar ataxia*
**作者**：Yokota T, et al.
**摘要**：探讨PRKCG基因突变与自身抗体在脊髓小脑共济失调(SCA)中的作用，发现部分SCA亚型患者同时存在基因异常和自身免疫反应，提示双重病理机制的可能性。
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**提示**：以上文献可通过PubMed或学术数据库(如Google Scholar)进一步检索全文。研究多聚焦于PRKCG抗体在神经免疫疾病中的诊断意义及致病机制。
The PRKCG antibody targets protein kinase C gamma (PKCγ), a member of the protein kinase C (PKC) family, which plays critical roles in signal transduction and cellular regulation. Encoded by the PRKCG gene, PKCγ belongs to the classical PKC subfamily (cPKC), characterized by its dependence on calcium ions and diacylglycerol (DAG) for activation. It is predominantly expressed in the central nervous system, particularly in cerebellar Purkinje cells and select neuronal populations, where it regulates synaptic plasticity, neuronal development, and memory formation. Structurally, PKCγ contains regulatory (C1 and C2 domains) and catalytic kinase domains, enabling its involvement in phosphorylation-dependent signaling cascades.
Mutations in PRKCG are linked to spinocerebellar ataxia type 14 (SCA14), a neurodegenerative disorder marked by progressive motor coordination deficits. PRKCG antibodies are widely used in research to study PKCγ expression, localization, and function in both physiological and pathological contexts. They enable techniques like Western blotting, immunohistochemistry, and immunofluorescence to investigate PKCγ's role in neurological diseases, cancer, and immune responses. Clinically, these antibodies aid in diagnosing SCA14 and understanding molecular mechanisms underlying PKCγ-associated pathologies. Their specificity and reliability make them essential tools for dissecting PKC signaling pathways and developing targeted therapies.
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