Rabbit Polyclonal ASCC2 Antibody

The ASCC2 (Activating Signal Cointegrator 2 Complex Component 2) antibody is a tool used to study the ASCC2 protein, a subunit of the ASC-1 (Activating Signal Cointegrator-1) complex. This nuclear complex plays roles in transcriptional regulation, DNA repair, and cellular stress responses. ASCC2 is involved in mediating interactions between transcription factors and the basal transcriptional machinery, particularly through its association with RNA polymerase II. It also participates in resolving R-loops (RNA-DNA hybrids) and maintaining genome stability. Research highlights its critical function in the alkylation damage repair pathway, where the ASCC complex promotes dealkylation of mutagenic DNA adducts via the ALKBH3 demethylase. Dysregulation of ASCC2 has been linked to cancer progression, including metastasis and chemoresistance. The ASCC2 antibody is widely employed in techniques like Western blotting, immunoprecipitation, and immunofluorescence to detect protein expression, localization, and interactions in cellular models or tissues. Recent studies explore its role in diseases such as colorectal cancer, lung adenocarcinoma, and neurological disorders, emphasizing its impact on cell proliferation, migration, and TGF-β signaling pathways. Validated antibodies are essential for elucidating ASCC2's molecular mechanisms and therapeutic potential.