Rabbit Polyclonal DEFA1B Antibody

The DEFA1B antibody targets the DEFA1B protein, a member of the α-defensin family, which plays a critical role in innate immunity. α-Defensins are small, cationic antimicrobial peptides produced primarily by neutrophils and certain epithelial cells. They exhibit broad-spectrum activity against bacteria, viruses, and fungi, while also modulating immune responses. The DEFA1 gene, located on chromosome 8p23.1. encodes multiple variants, including DEFA1A and DEFA1B, which differ by a single amino acid substitution (DEFA1B has a valine instead of an isoleucine at position 34). Despite this minor variation, DEFA1B retains functional similarities to other α-defensins, contributing to microbial killing, chemotaxis, and wound healing. Antibodies against DEFA1B are essential tools for studying its expression, localization, and role in diseases. Research has linked altered α-defensin levels to conditions like inflammatory bowel disease, chronic obstructive pulmonary disease, and certain cancers. DEFA1B-specific antibodies help distinguish its activity from other isoforms, aiding investigations into isoform-specific functions or genetic variations. These antibodies are also used in diagnostic assays to quantify DEFA1B in clinical samples, potentially serving as biomarkers for infection or inflammation. Additionally, they support therapeutic development by identifying defensin-related pathways as targets for immunomodulation or antimicrobial strategies.