| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | ADNP1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ADNP |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ADNP抗体的参考文献示例(注：内容为示例性概括，非真实文献)：
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1. **文献名称**: *ADNP Antibody-Based Detection of Neuronal Expression Changes in Helsmoortel-Van der Aa Syndrome Models*
**作者**: Breyne, J. et al. (2022)
**摘要**: 研究利用特异性ADNP抗体分析ADNP综合征患者来源的神经元细胞模型，发现ADNP蛋白表达水平显著降低，并与其突触功能异常相关，提示ADNP抗体可作为该综合征的分子诊断工具。
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2. **文献名称**: *Neuroprotective Role of ADNP in Alzheimer's Disease: Insights from Antibody-Mediated Localization*
**作者**: Ostapchenko, V.G. et al. (2020)
**摘要**: 通过免疫组化结合ADNP抗体，揭示ADNP在阿尔茨海默病小鼠脑组织中的分布变化，表明其在淀粉样蛋白沉积区域的表达上调可能具有神经保护作用。
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3. **文献名称**: *Development of a High-Sensitivity ELISA for ADNP Quantification in Human Serum Using Novel Monoclonal Antibodies*
**作者**: Smith, L. & Chen, R. (2021)
**摘要**: 研究报道了一种基于新型ADNP单克隆抗体的ELISA检测方法，能够高灵敏度定量人血清中的ADNP水平，为ADNP相关神经发育障碍的无创诊断提供潜在方案。
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(注：如需真实文献，建议通过PubMed或Google Scholar搜索关键词“ADNP antibody”或“ADNP biomarker”获取最新研究。)
ADNP (Activity-Dependent Neuroprotective Protein) antibodies are critical tools for studying the expression and function of the ADNP protein, a key regulator of brain development and neuroprotection. ADNP, first identified in 1999. is highly expressed in the central nervous system and plays essential roles in neuronal survival, synaptic plasticity, and chromatin remodeling. It interacts with microtubules and participates in neurogenesis, while its neuroprotective properties are activated in response to cellular stress or injury. Mutations in the ADNP gene cause ADNP syndrome (Helsmoortel-Van der Aa syndrome), a rare neurodevelopmental disorder linked to autism spectrum traits, intellectual disability, and distinctive facial features.
ADNP antibodies enable researchers to detect and quantify ADNP protein levels in tissues or cell cultures using techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies have advanced studies exploring ADNP's role in neurodevelopmental disorders, neurodegenerative diseases (e.g., Alzheimer’s), and cancer, where ADNP dysregulation is implicated in tumor progression. Recent research also highlights ADNP's involvement in DNA repair and epigenetic regulation through its interaction with chromatin-remodeling complexes. Commercially available ADNP antibodies vary in specificity, targeting different epitopes (e.g., N-terminal or C-terminal regions), requiring validation for experimental consistency. Ongoing work focuses on therapeutic strategies targeting ADNP pathways, emphasizing the antibody's importance in both diagnostic and mechanistic research.
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