| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/15-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | APS |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Synthetic peptide of human SH2B2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SH2B2抗体的3篇文献示例(部分为假设性描述，仅供参考)：
1. **文献名称**：*SH2B2 regulates insulin receptor signaling through its interaction with IRS-1*
**作者**：Li Y, et al.
**摘要**：该研究利用SH2B2特异性抗体，通过免疫共沉淀和Western blot技术，揭示了SH2B2通过结合IRS-1增强胰岛素受体下游的PI3K/AKT通路活性，表明其在代谢调控中的关键作用。
2. **文献名称**：*Role of SH2B2 in T-cell activation and immune response*
**作者**：Wang H, et al.
**摘要**：通过SH2B2抗体阻断实验，研究发现SH2B2通过调控TCR信号通路中的ZAP-70磷酸化，影响T细胞增殖和细胞因子分泌，为免疫相关疾病治疗提供了潜在靶点。
3. **文献名称**：*SH2B2 expression correlates with leukemia progression and drug resistance*
**作者**：Zhang Q, et al.
**摘要**：使用SH2B2抗体进行免疫组化分析，发现SH2B2在急性髓系白血病(AML)患者中高表达，且与化疗耐药性相关，提示其作为预后标志物的潜力。
**注**：以上文献为示例性描述，实际研究中请通过PubMed或Google Scholar以“SH2B2 antibody”或“SH2B2 function”为关键词检索最新文献。若需具体文献，可提供更详细的研究方向或背景。
SH2B2 (Src homology 2 B adapter protein 2), also known as APS, is an adapter protein involved in regulating cellular signaling pathways. It belongs to the SH2B family of adapters, characterized by a pleckstrin homology (PH) domain, an SH2 domain, and dimerization motifs. SH2B2 interacts with receptor tyrosine kinases (e.g., Trk receptors) and cytokine receptors (e.g., JAK2) to modulate downstream signaling cascades, including PI3K/AKT, MAPK, and STAT pathways. It plays roles in energy metabolism, cell proliferation, and immune regulation. Dysregulation of SH2B2 has been implicated in metabolic disorders (e.g., obesity, diabetes) and cancers, where it may act as a tumor suppressor or promoter depending on context.
Antibodies targeting SH2B2 are critical research tools for investigating its expression, localization, and molecular interactions. They enable detection of SH2B2 in tissues or cells via techniques like Western blot, immunohistochemistry, and flow cytometry. Such antibodies help elucidate SH2B2's dual roles in metabolic homeostasis (e.g., enhancing insulin/leptin signaling) and cancer progression (e.g., modulating JAK2/STAT3 in leukemia). Additionally, SH2B2 antibodies are explored for therapeutic potential, as blocking SH2B2-receptor interactions could modulate pathological signaling in diseases like obesity-linked malignancies. However, functional studies remain ongoing to clarify its context-dependent mechanisms and therapeutic applicability.
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