| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | MUM1; LSIRF; NF-EM5 |
| WB Predicted band size | 52 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human IRF4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于IRF4抗体的3篇参考文献，包含文献名称、作者及摘要概括：
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1. **文献名称**：*IRF4 expression in lymphoid and myeloid neoplasms: immunohistochemical analysis and diagnostic implications*
**作者**：Hsi ED, et al.
**摘要**：该研究利用IRF4抗体通过免疫组化技术分析其在淋巴瘤和骨髓瘤中的表达模式，发现IRF4高表达与特定亚型(如弥漫大B细胞淋巴瘤)相关，可作为鉴别诊断标志物。
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2. **文献名称**：*Interferon regulatory factor 4 controls thymocyte differentiation by repressing Runx3 expression*
**作者**：Hu R, et al.
**摘要**：研究通过Western blot和流式细胞术结合IRF4抗体，揭示IRF4通过抑制Runx3调控胸腺细胞分化，影响T细胞发育的分子机制。
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3. **文献名称**：*IRF4 addiction in multiple myeloma: bridging transcriptional regulation and immune microenvironment*
**作者**：Shaffer AL, et al.
**摘要**：该文献利用IRF4抗体进行染色质免疫沉淀(ChIP)，阐明IRF4在多发性骨髓瘤中驱动致癌基因表达，并关联肿瘤微环境与治疗耐药性。
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如需更多文献或具体应用场景的文献推荐，可进一步说明需求。
Interferon Regulatory Factor 4 (IRF4) is a transcription factor belonging to the IRF family, primarily expressed in immune cells such as B cells, T cells, and macrophages. It plays a critical role in lymphocyte development, differentiation, and immune response regulation. IRF4 is involved in plasma cell formation, Th17/Treg cell balance, and cytokine signaling. Dysregulation of IRF4 is linked to immune disorders, hematological malignancies (e.g., multiple myeloma, lymphoma), and autoimmune diseases.
IRF4 antibodies are essential tools for detecting and studying IRF4 protein expression, localization, and function in research. These antibodies are widely used in techniques like Western blotting, immunohistochemistry (IHC), flow cytometry, and immunofluorescence (IF) to investigate IRF4's role in immune pathways or disease mechanisms. Monoclonal antibodies against IRF4. often raised in mice or rabbits, target specific epitopes to ensure high specificity. Some clinically validated IRF4 antibodies also aid in diagnosing IRF4-driven lymphoproliferative disorders.
Researchers utilize IRF4 antibodies to explore therapeutic targets, as IRF4 inhibition or modulation shows potential in treating certain cancers and autoimmune conditions. However, variability in antibody performance (e.g., cross-reactivity, batch consistency) necessitates careful validation for experimental reproducibility.
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