| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | OPSMD; SHIP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human INPPL1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于INPPL1(SHIP2)抗体的代表性文献示例(内容基于真实研究方向，文献标题与作者为虚拟示例)：
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1. **文献名称**: *"SHIP2 regulates insulin sensitivity through Akt signaling in adipocytes"*
**作者**: Tanaka K, et al.
**摘要**: 本研究使用INPPL1特异性抗体(克隆号：3F5)通过Western blot和免疫沉淀技术，发现SHIP2通过负调控PI3K-Akt通路影响脂肪细胞胰岛素敏感性，为2型糖尿病机制提供了新见解。
2. **文献名称**: *"INPPL1 expression correlates with tumor metastasis in triple-negative breast cancer"*
**作者**: Chen L, et al.
**摘要**: 通过免疫组化(抗INPPL1抗体：Abcam #ab12345)分析乳腺癌组织，发现INPPL1高表达与TNBC患者淋巴结转移显著相关，提示其可能作为癌症预后标志物。
3. **文献名称**: *"Structural insights into SHIP2 phosphatase domain interaction with therapeutic inhibitors"*
**作者**: Patel R, et al.
**摘要**: 利用INPPL1抗体(Cell Signaling #6789)进行蛋白质印迹验证重组SHIP2结构域表达，结合X射线晶体学揭示小分子抑制剂靶向SHIP2催化结构域的作用机制。
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**注**: 以上文献为示例模板，实际引用需以具体研究对应的真实文献为准。建议通过PubMed或Google Scholar检索关键词“INPPL1 antibody”、“SHIP2 antibody”及研究领域(如“cancer”或“diabetes”)获取最新文献。
The INPPL1 gene encodes the inositol polyphosphate phosphatase-like 1 protein, also known as SH2-containing inositol 5'-phosphatase 2 (SHIP2). This protein belongs to the inositol polyphosphate 5-phosphatase family, which regulates cellular signaling by hydrolyzing phosphatidylinositol (3.4.5)-trisphosphate (PIP3) to phosphatidylinositol (3.4)-bisphosphate (PI(3.4)P2). SHIP2 plays a critical role in modulating insulin signaling, receptor tyrosine kinase pathways, and other processes linked to cell growth, survival, and metabolic homeostasis. Its activity impacts downstream effectors like AKT/PKB and MAPK, influencing glucose uptake, apoptosis, and cytoskeletal organization.
INPPL1 antibodies are widely used in research to detect SHIP2 expression, localization, and interactions in various tissues and disease models. Dysregulation of SHIP2 has been implicated in insulin resistance, type 2 diabetes, obesity, and cancer, making these antibodies valuable tools for studying metabolic disorders and oncogenesis. They are employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to explore SHIP2's role in cellular pathways and its potential as a therapeutic target. Commercially available antibodies are typically validated for specificity against human, mouse, or rat isoforms, aiding cross-species comparative studies. Research using INPPL1 antibodies continues to uncover its complex regulatory mechanisms and pathophysiological relevance.
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