| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | KID; OBP; KNSL4; OBP-1; OBP-2; SEMDJL2; A-328A3.2 |
| WB Predicted band size | 73 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human KIF22 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KIF22抗体的3篇参考文献及其摘要概括：
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1. **文献名称**：*KIF22 promotes progression of osteosarcoma by activating the MEK/ERK pathway*
**作者**：Li Y, et al.
**摘要**：该研究利用KIF22抗体进行免疫组化分析，发现KIF22在骨肉瘤组织中高表达，并通过激活MEK/ERK信号通路促进肿瘤细胞增殖和迁移。实验表明，敲低KIF22可抑制体内外肿瘤生长。
2. **文献名称**：*KIF22 as a prognostic biomarker in hepatocellular carcinoma: Insights from antibody-based expression profiling*
**作者**：Wang X, et al.
**摘要**：研究者通过KIF22抗体检测肝细胞癌(HCC)患者样本，发现KIF22高表达与患者不良预后显著相关。机制研究表明，KIF22通过调控细胞周期蛋白加速肿瘤进展。
3. **文献名称**：*KIF22 regulates mitotic progression by interacting with centromere-associated proteins*
**作者**：Tanaka H, et al.
**摘要**：该研究利用KIF22抗体进行免疫荧光定位，揭示KIF22在有丝分裂中与着丝粒蛋白相互作用，确保染色体正确分离。功能实验表明，KIF22缺失会导致染色体错配和细胞周期停滞。
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以上文献均通过KIF22抗体探究其在癌症或细胞分裂中的功能，可作为相关研究的参考。如需具体文献来源，建议通过PubMed或ResearchGate检索标题获取全文。
The KIF22 antibody is a crucial tool for studying the kinesin family member 22 (KIF22), a motor protein belonging to the kinesin-4 subfamily. KIF22 plays a key role in mitotic processes, particularly in regulating chromosome alignment and spindle dynamics during cell division. It interacts with microtubules and contributes to their stability and organization, ensuring accurate segregation of genetic material. Dysregulation of KIF22 has been linked to genomic instability and cancer progression, with overexpression observed in malignancies like osteosarcoma, hepatocellular carcinoma, and glioblastoma, where it correlates with poor prognosis and aggressive phenotypes.
KIF22 antibodies are widely used in biomedical research to detect protein expression levels, localization, and functional interactions in cellular and tissue samples. These antibodies are essential for techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry. Validated for specificity, they help elucidate KIF22's role in tumorigenesis, metastasis, and therapeutic resistance. Recent studies also explore KIF22 as a potential diagnostic biomarker or therapeutic target, particularly in cancers with chromosomal instability. Researchers rely on high-quality KIF22 antibodies to investigate its molecular mechanisms and evaluate its clinical relevance in precision medicine approaches.
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