| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HBETA3; KCNMB2; KCNMBL; BKBETA3; SLOBETA3; SLO-BETA-3; K(VCA)BETA-3 |
| WB Predicted band size | 32 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human KCNMB3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于KCNMB3抗体的3篇参考文献示例(内容为模拟概括，仅供参考)：
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1. **文献名称**: "Characterization of KCNMB3 Antibody Specificity in Smooth Muscle Tissues"
**作者**: Smith A, et al.
**摘要**: 研究验证了KCNMB3抗体在多种平滑肌组织中的特异性，通过Western blot和免疫组化证实其在BK通道β3亚基检测中的可靠性，并探讨其与血管张力调节的关联。
2. **文献名称**: "KCNMB3 Isoform Expression in Human Tumors: A Prognostic Marker Study"
**作者**: Lee B, et al.
**摘要**: 利用KCNMB3抗体分析其在结直肠癌等肿瘤中的表达模式，发现高表达与患者生存率相关，提示其可能作为潜在生物标志物。
3. **文献名称**: "Role of KCNMB3 in Neuronal BK Channel Modulation"
**作者**: Garcia C, et al.
**摘要**: 通过免疫荧光和共聚焦显微镜技术，研究KCNMB3抗体标记的β3亚基在神经元中的分布，揭示其对钙敏感性及癫痫样放电的调控作用。
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注：以上为模拟内容，实际文献需通过PubMed、Google Scholar等平台检索关键词(如KCNMB3 antibody、BK channel beta subunit)获取。
The KCNMB3 antibody is a research tool designed to detect and study the potassium calcium-activated channel subfamily M regulatory beta subunit 3 (KCNMB3), a protein encoded by the *KCNMB3* gene. This subunit modulates the activity of large-conductance calcium- and voltage-activated potassium (BK) channels, which play critical roles in regulating cellular excitability, vascular tone, and neurotransmitter release. KCNMB3 is one of four β-subunits (β1-β4) that influence BK channel kinetics, calcium sensitivity, and tissue-specific functions. It is predominantly expressed in tissues such as the brain, smooth muscle, and endocrine glands.
Antibodies targeting KCNMB3 are used in applications like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression, localization, and interaction with BK channel α-subunits (e.g., KCNMA1). Research involving KCNMB3 antibodies has explored its role in physiological processes, including blood pressure regulation and neuronal signaling, as well as pathological conditions like hypertension, epilepsy, and cancer. For instance, altered KCNMB3 expression has been linked to tumor progression in certain cancers, suggesting its potential as a biomarker or therapeutic target.
These antibodies are typically validated for specificity using knockout controls or siRNA-based silencing to ensure accurate detection. Their development supports ongoing studies into BK channel diversity and the molecular mechanisms underlying diseases associated with KCNMB3 dysfunction.
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