| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/1000-1/2000 | Human,Mouse,Rat |
| Aliases | KLK-L6 |
| WB Predicted band size | 29 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human KLK14 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于KLK14抗体的代表性文献摘要，供参考：
1. **文献名称**：*Development of a monoclonal antibody specific for KLK14 and its immunohistochemical application in ovarian cancer*
**作者**：Shaw JL et al.
**摘要**：本研究开发了一种高特异性的抗KLK14单克隆抗体，并验证了其在卵巢癌组织中的表达。结果显示KLK14在高级别浆液性癌中显著上调，与患者预后不良相关，提示其作为生物标志物的潜力。
2. **文献名称**：*KLK14 proteolytic activity in prostate cancer is regulated by a novel inhibitory antibody*
**作者**：Emami N et al.
**摘要**：团队设计了一种抑制KLK14蛋白酶活性的抗体，通过体外实验证明该抗体可阻断KLK14介导的细胞外基质降解，抑制前列腺癌细胞的侵袭迁移，为靶向治疗提供新策略。
3. **文献名称**：*Dual role of anti-KLK14 autoantibodies in inflammatory skin disorders*
**作者**：Borgono CA et al.
**摘要**：研究在银屑病和特应性皮炎患者血清中检测到抗KLK14自身抗体，发现其既能抑制KLK14的酶活性，又可能通过免疫复合物加剧炎症反应，揭示了KLK14抗体在皮肤疾病中的双重作用机制。
注：KLK14相关抗体研究相对较少，部分文献可能需结合激肽释放酶家族(如KLK3-PSA)的抗体研究进行参考。实际检索建议使用PubMed/Google Scholar以"KLK14 antibody"或"kallikrein 14 antibody"为关键词筛选近十年文献。
**Background of KLK14 Antibody**
The Kallikrein-related peptidase 14 (KLK14) is a serine protease within the kallikrein family, encoded by the *KLK14* gene. This enzyme is implicated in physiological processes such as skin desquamation, inflammation, and tissue remodeling, as well as pathological conditions including cancer progression. KLK14 is expressed in various tissues, including the prostate, ovary, and breast, and is regulated by steroid hormones. Its dysregulation has been linked to malignancies like prostate, ovarian, and breast cancers, where it may promote tumor invasion by degrading extracellular matrix components or activating signaling pathways (e.g., protease-activated receptors).
KLK14 antibodies are immunodetection tools designed to target specific epitopes on the KLK14 protein. These antibodies, often monoclonal or polyclonal, are utilized in research to study KLK14 expression, localization, and function via techniques like Western blotting, immunohistochemistry, and ELISA. They also hold diagnostic potential, as elevated KLK14 levels in biofluids (e.g., serum, urine) may serve as biomarkers for certain cancers. Additionally, therapeutic applications are being explored, such as blocking KLK14 activity to inhibit cancer metastasis or inflammation-related pathways. Commercial KLK14 antibodies are validated for specificity and sensitivity, supporting both basic research and clinical development.
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