| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/10000 | Human,Mouse,Rat |
| Aliases | HUB; HELN1; HEL-N1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Synthetic peptide of human ELAVL2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ELAVL2抗体的3篇参考文献示例(内容基于真实文献改编，具体文献请通过学术数据库核实)：
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1. **文献名称**: *ELAVL2/HuB regulates neuronal differentiation through mRNA stability control in neuroblastoma cells*
**作者**: Smith A et al.
**摘要**: 本研究利用ELAVL2特异性抗体进行免疫沉淀和Western blot分析，发现ELAVL2通过结合靶mRNA(如MYCN)调控其稳定性，影响神经母细胞瘤细胞的分化进程。
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2. **文献名称**: *Differential expression of ELAVL2 in Alzheimer's disease post-mortem brain tissue*
**作者**: Chen L et al.
**摘要**: 通过ELAVL2抗体进行免疫组化染色，作者发现阿尔茨海默病患者海马区ELAVL2蛋白表达显著降低，提示其与神经退行性病变中RNA代谢异常相关。
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3. **文献名称**: *HuB/ELAVL2 antibody validation for RNA-protein interaction studies in neural development*
**作者**: Park J et al.
**摘要**: 该文献系统验证了ELAVL2抗体的特异性，并应用于斑马鱼胚胎的免疫荧光实验，证明ELAVL2在神经发育早期阶段调控mRNA的亚细胞定位。
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**注意**：以上文献信息为模拟示例，建议通过PubMed、Google Scholar等平台以关键词“ELAVL2 antibody”或“HuB antibody”检索真实文献。
The ELAVL2 antibody targets the ELAVL2 protein, a member of the Embryonic Lethal Abnormal Vision-like (ELAVL/Hu) family of RNA-binding proteins. ELAVL2. also known as HuB, plays a critical role in post-transcriptional gene regulation by stabilizing mRNA and enhancing translation, particularly in neuronal and germline tissues. It is involved in neurodevelopment, synaptic plasticity, and maintaining neuronal function. Dysregulation of ELAVL2 has been linked to neurological disorders, cancers, and neurodegenerative diseases.
ELAVL2 antibodies are widely used in research to study its expression, localization, and interactions in cellular and tissue contexts. These antibodies enable detection via techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). Commercial ELAVL2 antibodies are typically raised in rabbits or mice, with validation in specific experimental models.
Research applications include investigating ELAVL2's role in mRNA stability during neural differentiation, its overexpression in glioblastoma, and its potential as a biomarker. Cross-reactivity with other ELAVL family members (e.g., HuR, HuC, HuD) is a key consideration, requiring validation via knockout controls or epitope-specific designs.
Overall, ELAVL2 antibodies are essential tools for exploring RNA-protein dynamics in health and disease, particularly in neuroscience and oncology.
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