| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | CWS4; KILLIN |
| WB Predicted band size | 20 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human KLLN |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇模拟的关于KLLN抗体的参考文献示例(实际文献需通过学术数据库检索确认)：
---
1. **文献名称**：*KLLN Antibody as a Novel Biomarker in PTEN-deficient Tumors*
**作者**：Smith A, et al.
**摘要**：研究验证了KLLN抗体在PTEN基因缺失的肿瘤组织中的特异性表达，发现其可作为区分PTEN相关癌症亚型的潜在诊断标志物。
---
2. **文献名称**：*Functional Characterization of KLLN Protein in DNA Damage Response*
**作者**：Lee J, et al.
**摘要**：通过KLLN抗体的免疫沉淀技术，揭示了KLLN蛋白在调控细胞周期和DNA损伤修复通路中的作用，提示其与基因组稳定性相关。
---
3. **文献名称**：*KLLN Expression Analysis in Hereditary Cancer Syndromes*
**作者**：Garcia R, et al.
**摘要**：利用KLLN抗体对家族性癌症患者组织样本进行免疫组化分析，发现KLLN表达缺失与特定遗传性癌症风险升高显著相关。
---
**注意**：以上为模拟示例，实际文献需通过PubMed、Google Scholar等平台检索关键词“KLLN antibody”或“KLLN gene function”获取。KLLN基因与PTEN基因邻近，常参与肿瘤抑制和细胞周期调控研究。
KLLN antibody is a research tool targeting the KLLN protein, encoded by the *KLLN* gene located on chromosome 10q23.3. This locus is notable for housing the *PTEN* tumor suppressor gene, with *KLLN* situated adjacent to it. Discovered in 2008. KLLN (also termed "killin") shares a bidirectional promoter with *PTEN* but is transcribed in the opposite direction. KLLN functions as a p53-regulated DNA replication inhibitor, playing a role in cell cycle arrest and apoptosis. Its tumor-suppressive activity involves binding to replication origins to prevent unscheduled DNA synthesis, thereby maintaining genomic stability.
Dysregulation of KLLN, often due to promoter hypermethylation or genetic alterations, is implicated in various cancers, including breast, prostate, and endometrial carcinomas. Loss of KLLN expression correlates with tumor progression and poor prognosis, highlighting its potential as a biomarker. KLLN antibodies are primarily used in research to detect protein expression in tissues or cell lines, aiding studies on its interaction with PTEN, regulatory mechanisms, and therapeutic implications. These antibodies also help explore epigenetic silencing events in cancer and evaluate KLLN's role in chemosensitivity. Despite its functional overlap with PTEN, KLLN exhibits distinct molecular pathways, making it a unique target for understanding tumorigenesis and developing precision oncology strategies.
×
