| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | P53AIP1 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthetic peptide of human TP53AIP1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下为3篇关于TP53AIP1抗体的示例参考文献(注：文献为模拟示例，实际引用请通过学术数据库核实)：
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1. **"Characterization of a novel monoclonal antibody against TP53AIP1 for apoptosis detection"**
*作者：Li, X., et al.*
摘要：该研究开发了一种新型抗TP53AIP1单克隆抗体，验证其在Western blot和免疫荧光中的特异性，证明其在p53依赖性凋亡通路中检测TP53AIP1表达的可靠性。
2. **"TP53AIP1 antibody reveals its prognostic role in colorectal cancer"**
*作者：Wang, Y., et al.*
摘要：通过免疫组化分析临床样本，发现TP53AIP1高表达与结直肠癌患者生存率正相关，所用抗体成功标记肿瘤组织中的TP53AIP1蛋白，支持其作为预后标志物的潜力。
3. **"Dynamic regulation of TP53AIP1 in DNA damage response using specific antibodies"**
*作者：Suzuki, T., et al.*
摘要：研究利用TP53AIP1抗体追踪DNA损伤后该蛋白的亚细胞定位变化，揭示其在p53介导的线粒体凋亡通路中的时序性调控机制。
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如需实际文献，建议通过**PubMed**或**Google Scholar**搜索关键词“TP53AIP1 antibody”或“TP53AIP1 immunohistochemistry”获取最新研究。
The TP53AIP1 (Tumor Protein 53-Activated Intracellular Protein 1) antibody is a critical tool for studying the functional dynamics of the TP53AIP1 protein, a key mediator of p53-dependent apoptosis. TP53AIP1 is a nuclear-encoded mitochondrial protein transcriptionally activated by the tumor suppressor p53 in response to severe DNA damage. Its induction triggers mitochondrial membrane permeabilization, cytochrome c release, and caspase activation, ultimately promoting programmed cell death. This pathway underscores its role as a tumor suppressor, with dysregulation linked to cancer progression and chemoresistance.
Antibodies targeting TP53AIP1 enable researchers to detect and quantify its expression in cells or tissues using techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies are essential for investigating TP53AIP1's regulation, its interaction with p53 under stress conditions, and its involvement in apoptosis signaling networks. Validated antibodies typically demonstrate specificity for human TP53AIP1. though cross-reactivity with orthologs in model organisms (e.g., mice) may vary depending on epitope conservation.
Research applications span oncology, particularly in cancers with p53 mutations or defective apoptotic responses, where TP53AIP1 expression may correlate with therapeutic outcomes. Commercially available TP53AIP1 antibodies are often raised in rabbits or mice, with validation data including knockdown controls or peptide blocking assays to confirm specificity. Their use advances understanding of p53-mediated tumor suppression and supports drug discovery targeting apoptotic pathways.
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