| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | PAPA; DIPLA1; PAPP-A; PAPPA1; ASBABP2; IGFBP-4ase |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human PAPPA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及PAPPA抗体的代表性文献概览(注意：文献标题和作者为虚构示例，实际研究需通过学术数据库检索)：
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1. **标题**: *PAPP-A as a Novel Therapeutic Target in Atherosclerosis*
**作者**: Smith J, et al.
**摘要**: 研究探讨PAPPA抗体在抑制动脉粥样硬化斑块进展中的作用，发现其通过阻断PAPPA介导的IGF-1释放，显著减少小鼠模型中的炎症反应和斑块形成。
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2. **标题**: *Development of a High-Sensitivity ELISA for PAPPA Using Monoclonal Antibodies*
**作者**: Chen L, et al.
**摘要**: 报道一种基于单克隆抗体的新型PAPPA检测方法，可提升孕早期唐氏综合征筛查的准确性，并验证其在临床样本中的灵敏度和特异性。
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3. **标题**: *PAPPA Antibodies in Ovarian Cancer Prognosis*
**作者**: Wang Y, et al.
**摘要**: 分析PAPPA抗体检测在卵巢癌患者血清中的表达水平，发现高PAPPA浓度与肿瘤侵袭性和不良预后相关，提示其作为潜在生物标志物的价值。
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**提示**：实际文献需通过PubMed或Google Scholar检索关键词如"PAPPA antibody"、"PAPP-A immunotherapy"等，重点筛查以下领域：
- **临床应用**：产前筛查、心血管疾病诊断
- **机制研究**：PAPPA蛋白水解功能及抗体干预
- **技术开发**：抗体检测方法优化(如ELISA、化学发光法)
Pregnancy-associated plasma protein-A (PAPP-A) is a metalloproteinase first identified in the 1970s as a high-molecular-weight glycoprotein abundantly present in the serum of pregnant individuals. It belongs to the metzincin superfamily and plays a critical role in regulating insulin-like growth factor (IGF) signaling by cleaving insulin-like growth factor-binding proteins (IGFBPs), particularly IGFBP-4. thereby releasing bioactive IGF to promote cell growth and tissue repair. Beyond pregnancy, PAPP-A is implicated in cardiovascular diseases, cancer, and aging-related conditions due to its involvement in extracellular matrix remodeling and cellular proliferation.
PAPP-A antibodies are essential tools for both research and clinical diagnostics. In prenatal screening, anti-PAPP-A antibodies are used in first-trimester combined tests to measure maternal serum PAPP-A levels, as low concentrations correlate with an increased risk of chromosomal abnormalities like Down syndrome. In cardiovascular research, these antibodies help detect PAPP-A overexpression in unstable atherosclerotic plaques, linked to acute coronary events. Additionally, PAPP-A antibodies aid in studying its oncogenic roles in cancers, where elevated PAPP-A expression may drive tumor progression.
Available as monoclonal or polyclonal variants, these antibodies are validated for techniques such as ELISA, immunohistochemistry, and Western blot. Challenges include ensuring specificity due to structural similarities with related proteases. Ongoing research focuses on therapeutic applications, including PAPP-A inhibition strategies for age-related diseases. Overall, PAPP-A antibodies remain pivotal in elucidating biological mechanisms and improving diagnostic accuracy across multiple medical fields.
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