| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human RAB24 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RAB24抗体的3篇文献示例(注：文献信息为模拟示例，仅供参考)：
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1. **文献名称**: "RAB24 regulates autophagosome maturation through interactions with ATG8 family proteins"
**作者**: Zhang L, et al.
**摘要**: 本研究利用特异性抗RAB24抗体(兔多克隆抗体)，通过免疫荧光和共聚焦显微镜技术，揭示了RAB24在自噬体与溶酶体融合中的关键作用，并证实其与LC3蛋白的相互作用依赖于其GTP酶活性。
2. **文献名称**: "Development and validation of a monoclonal antibody for RAB24 in human cancer tissues"
**作者**: Tanaka K, et al.
**摘要**: 文章报道了一种新型小鼠单克隆抗体的开发，该抗体针对人源RAB24蛋白的C端结构域。通过免疫组化分析，研究发现RAB24在结直肠癌组织中表达上调，并与患者预后不良相关。
3. **文献名称**: "RAB24 modulates endoplasmic reticulum stress response: Evidence from siRNA and antibody-based knockdown studies"
**作者**: Smith J, et al.
**摘要**: 使用商业化RAB24抗体(货号：Abcam ab12345)进行Western blot和免疫沉淀实验，发现RAB24通过调控IRE1α通路参与内质网应激反应，提示其潜在治疗靶点价值。
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**备注**：以上文献信息为虚构示例，实际研究中建议通过PubMed、Web of Science等数据库检索真实文献(关键词：RAB24 antibody, RAB24 autophagy, RAB24 function)。如需具体文献，可提供更详细的研究背景以便进一步筛选。
RAB24 antibodies are immunological tools used to detect and study RAB24. a member of the RAS-associated binding (RAB) GTPase family involved in intracellular vesicular trafficking and autophagy regulation. RAB24. a small GTP-binding protein, shares structural homology with other RAB proteins but exhibits unique functional characteristics. It localizes to autophagosomes, lysosomes, and the endoplasmic reticulum, playing roles in autophagosome maturation, lysosomal degradation, and cellular stress responses. Dysregulation of RAB24 has been implicated in neurodegenerative diseases, cancer, and immune disorders, making it a target for mechanistic studies.
RAB24 antibodies are typically developed in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. These antibodies enable researchers to investigate RAB24 expression, subcellular localization, and interactions via techniques such as Western blotting, immunofluorescence, and immunoprecipitation. Commercial antibodies often vary in specificity and applications depending on epitope regions and clonal types (monoclonal/polyclonal). Validation includes testing in knockout cell lines or tissues to confirm target specificity. Researchers utilize these antibodies to explore RAB24's involvement in autophagy-lysosomal pathways, membrane trafficking dynamics, and disease mechanisms, particularly in contexts like tumor progression or protein aggregation disorders. Proper controls are critical due to potential cross-reactivity with other RAB family members.
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