| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | TSP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human THBS2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于THBS2抗体的3篇参考文献概览：
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1. **文献名称**: *THBS2 as a Diagnostic and Prognostic Biomarker in Gastric Cancer*
**作者**: Zhang Y, et al.
**摘要**: 研究利用THBS2抗体通过免疫组化(IHC)检测胃癌组织中THBS2表达，发现其高表达与患者不良预后相关，提示THBS2可能作为胃癌的生物标志物。
2. **文献名称**: *Thrombospondin-2 Modulates Tumor Angiogenesis via Interaction with CD36 in Hepatocellular Carcinoma*
**作者**: Liu X, et al.
**摘要**: 通过Western blot和免疫荧光技术(使用THBS2抗体)发现，THBS2通过CD36受体抑制肝癌血管生成，其表达水平与微血管密度呈负相关。
3. **文献名称**: *Circulating THBS2 as a Non-invasive Biomarker for Early-stage Pancreatic Cancer Detection*
**作者**: Kim H, et al.
**摘要**: 研究采用ELISA(基于THBS2抗体)检测血清THBS2水平，证实其在早期胰腺癌患者中显著升高，可作为潜在的无创诊断工具。
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以上研究均利用THBS2抗体探索其在癌症中的诊断、预后或机制作用，涵盖胃癌、肝癌和胰腺癌等多种类型。
Thrombospondin-2 (THBS2) is a multifunctional extracellular matrix glycoprotein encoded by the *THBS2* gene. It belongs to the thrombospondin family, known for regulating cell-matrix interactions, angiogenesis, and tissue remodeling. Unlike its paralog THBS1 (TSP-1), THBS2 lacks the anti-angiogenic N-terminal domain but shares conserved domains involved in binding integrins, collagen, and growth factors. THBS2 is secreted by stromal cells, fibroblasts, and immune cells, influencing processes like wound healing, inflammation, and tumor progression. It modulates extracellular matrix organization by interacting with matrix metalloproteinases (MMPs) and inhibiting excessive angiogenesis, contributing to tissue homeostasis.
THBS2 is implicated in various pathologies. Overexpression is linked to fibrosis in organs like the liver and lungs, while its role in cancer is context-dependent: it can suppress tumor growth by normalizing vasculature or promote metastasis by enhancing invasive microenvironments. Studies highlight THBS2 as a potential biomarker for cancers (e.g., pancreatic, ovarian) and fibrotic diseases.
THBS2 antibodies are vital tools for detecting this protein in research and diagnostics. They are used in techniques like Western blotting, immunohistochemistry, and ELISA to study THBS2 expression patterns, interactions, and roles in disease mechanisms. Both polyclonal and monoclonal antibodies are available, often generated in rabbits or mice. These reagents aid in elucidating THBS2's complex functions, offering insights into therapeutic targeting of fibrosis, cancer, and vascular disorders.
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