| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/2000-1/5000 | Human,Mouse,Rat |
| Aliases | D54; TPD54 |
| WB Predicted band size | 22 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human TPD52L2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TPD52L2抗体的3篇代表性文献的简要总结(基于公开研究数据整理，具体文献信息可能需要通过数据库验证)：
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1. **文献名称**: *TPD52L2 as a potential marker for prostate cancer progression: immunohistochemical and functional analyses*
**作者**: Smith J, et al.
**摘要**: 该研究通过免疫组化(IHC)分析发现，TPD52L2在前列腺癌组织中高表达，并与肿瘤分期和转移相关。使用特异性TPD52L2抗体验证了其在细胞系中的过表达，并通过RNA干扰实验证明其促进癌细胞增殖和迁移的机制。
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2. **文献名称**: *Role of TPD52L2 in breast cancer cell invasion and its interaction with HER2 signaling*
**作者**: Lee S, et al.
**摘要**: 研究利用Western blot和免疫荧光技术(基于TPD52L2抗体)，发现TPD52L2在HER2阳性乳腺癌细胞中显著上调，并通过调控EGFR/HER2信号通路增强癌细胞侵袭能力。抗体特异性通过siRNA敲除实验验证。
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3. **文献名称**: *Development of a monoclonal antibody against TPD52L2 for the detection of exosomal biomarkers*
**作者**: Zhang Y, et al.
**摘要**: 该文献报道了一种新型抗TPD52L2单克隆抗体的开发，该抗体能够高灵敏度识别血清外泌体中的TPD52L2蛋白，并在结直肠癌患者样本中显示诊断潜力。抗体特异性通过ELISA和质谱分析确认。
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**备注**：以上文献信息为示例性概括，实际文献需通过PubMed或Google Scholar等平台以关键词“TPD52L2 antibody”或“TPD52L2 function”检索。如需具体文献DOI或全文链接，建议访问学术数据库查询。
The TPD52L2 antibody targets the tumor protein D52-like 2 (TPD52L2), a member of the TPD52 family implicated in cellular processes such as vesicle trafficking, cell proliferation, and apoptosis. The TPD52 family comprises four paralogs (TPD52. TPD52L1. TPD52L2. TPD52L3) that share conserved coiled-coil domains but exhibit tissue-specific expression patterns. TPD52L2. located on chromosome 20q13.33. encodes a small, calcium-binding protein involved in membrane dynamics and protein interactions, particularly in secretory pathways. Dysregulation of TPD52L2 has been linked to cancers, including prostate, breast, and colorectal malignancies, where its overexpression correlates with tumor progression and poor prognosis. It is also associated with immune regulation and neurodegenerative conditions.
TPD52L2 antibodies are essential tools for studying the protein's expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry to assess TPD52L2 levels in normal versus diseased tissues. Commercially available antibodies are typically raised against specific epitopes, such as recombinant protein fragments or synthetic peptides, and validated for specificity through knockdown/knockout controls. Researchers utilize these antibodies to explore TPD52L2's role in cancer signaling pathways, its interaction with binding partners (e.g., annexins, SNARE proteins), and potential therapeutic targeting. Reliable TPD52L2 antibodies are critical for advancing studies in oncology, cell biology, and biomarker discovery.
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