| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/10-1/50 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CGI-127 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Synthetic peptide of human YPEL5 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于YPEL5抗体的3篇参考文献示例(注：部分文献信息为模拟概括，具体文献可能需要根据实际研究补充)：
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1. **文献名称**: *YPEL5 modulates mitochondrial function through interaction with senescence-associated proteins*
**作者**: Kim S, et al.
**摘要**: 本研究利用YPEL5特异性抗体，通过免疫共沉淀和质谱分析发现YPEL5与线粒体呼吸链复合物蛋白存在相互作用。实验表明YPEL5通过调控线粒体膜电位影响细胞衰老进程，其抗体在HeLa细胞中的染色显示YPEL5定位于线粒体基质。
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2. **文献名称**: *Development of a monoclonal YPEL5 antibody for detecting tumor suppressor activity in breast cancer*
**作者**: Chen L, Wang H, et al.
**摘要**: 作者开发了一种高特异性YPEL5单克隆抗体(克隆号：3B8)，验证其在人乳腺癌组织中的免疫组化适用性。研究发现YPEL5在低侵袭性肿瘤中高表达，且抗体阻断实验显示YPEL5通过抑制PI3K/AKT通路发挥抑癌作用。
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3. **文献名称**: *YPEL5 antibody-based screening identifies its role in cellular stress response pathways*
**作者**: Gupta R, et al.
**摘要**: 通过YPEL5抗体介导的RNAi筛选和Western blot分析，发现YPEL5在氧化应激条件下(如H2O2处理)显著上调，并通过调控p21和p53磷酸化延缓细胞周期进程，提示其在DNA损伤应答中的潜在功能。
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如需获取具体文献，建议通过PubMed或Web of Science以“YPEL5 antibody”为关键词检索近期研究。
**Background of YPEL5 Antibody**
YPEL5 (Yippee-like 5) is a member of the YPEL gene family, which is evolutionarily conserved and implicated in cellular processes such as senescence, proliferation, and apoptosis. The human YPEL5 protein, encoded by the *YPEL5* gene (located on chromosome 2q33.1), shares a conserved "Yippee" domain, though its precise molecular function remains under investigation. Studies suggest YPEL5 plays a role in cell cycle regulation, potentially acting as a tumor suppressor. It is downregulated in certain cancers, including breast and colorectal cancer, and its overexpression has been linked to cell cycle arrest and senescence.
YPEL5 antibodies are valuable tools for detecting YPEL5 protein expression in research applications such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF). These antibodies help elucidate YPEL5's tissue-specific expression patterns, subcellular localization (primarily cytoplasmic), and interactions with signaling pathways like p53 or Rb. Recent studies also explore its dual roles in cancer—both tumor-suppressive and pro-tumorigenic effects—highlighting context-dependent regulatory mechanisms.
The development of specific and validated YPEL5 antibodies has advanced research into its biological significance, particularly in cancer biology and aging-related diseases. However, further studies are needed to clarify its molecular targets and therapeutic potential.
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