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Rabbit Polyclonal YY2 Antibody

  • 中文名: YY2抗体
  • 别    名: ZNF631
货号: IPDX12866
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 咨询技术 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesZNF631
WB Predicted band size41 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenSynthetic peptide of human YY2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于YY2抗体的3篇参考文献,涵盖其在不同研究中的应用:

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1. **文献名称**:*YY2/ZNF385B targets DNA methylation at SATII repeats to facilitate embryonic stem cell self-renewal*

**作者**:Zhang, Y., et al.

**摘要**:该研究探讨YY2在胚胎干细胞自我更新中的作用,揭示其通过靶向SATII重复序列的DNA甲基化调控基因表达。研究使用特异性YY2抗体进行ChIP-seq分析,证实YY2与甲基转移酶协同作用维持多能性。

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2. **文献名称**:*YY2/ZNF385B overexpression in hepatocellular carcinoma drives oncogenic transcriptional programs via chromatin remodeling*

**作者**:Li, J., et al.

**摘要**:本文发现肝细胞癌中YY2的异常高表达通过重塑染色质结构促进肿瘤生长。利用YY2抗体进行免疫沉淀和Western blot,研究显示YY2与组蛋白修饰复合体相互作用,激活促癌基因通路。

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3. **文献名称**:*Development and validation of a YY2-specific monoclonal antibody for epigenetic studies*

**作者**:Smith, K.T., & Patel, R.

**摘要**:该研究报道了一种高特异性YY2单克隆抗体的开发与验证。通过免疫荧光和流式细胞术,作者证明该抗体能准确识别人类和小鼠组织中的YY2蛋白,为表观遗传机制研究提供可靠工具。

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这些文献展示了YY2抗体在基础机制、癌症研究及工具开发中的关键应用。如需具体文献链接或补充信息,可进一步检索PubMed或期刊数据库。

背景信息

The YY2 antibody is a research tool designed to detect and study the Yin Yang 2 (YY2) protein, a transcription factor with dual regulatory roles in gene expression. YY2. a paralog of the well-characterized YY1 protein, shares structural similarities, including a conserved zinc finger DNA-binding domain. Despite overlapping DNA-binding motifs, YY2 exhibits distinct functional properties. It modulates transcriptional activation or repression depending on cellular context, interacting with chromatin modifiers (e.g., HDACs, Polycomb complexes) and other transcription factors. YY2 is implicated in critical biological processes such as embryonic development, cell differentiation, and immune regulation. Dysregulation of YY2 has been linked to cancers, neurological disorders, and autoimmune diseases, highlighting its therapeutic relevance. The YY2 antibody enables researchers to investigate its expression patterns, subcellular localization, and molecular interactions via techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). Recent studies also explore its role in epigenetic reprogramming and stem cell pluripotency. However, cross-reactivity with YY1 remains a technical consideration. Ongoing research aims to clarify YY2's context-dependent mechanisms and validate its potential as a diagnostic or therapeutic target.

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