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Rabbit Polyclonal XDH Antibody

  • 中文名： XDH抗体
  • 别    名： XO; XOR
货号: IPDX12868
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesXO; XOR
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human XDH
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于XDH(黄嘌呤脱氢酶)抗体的3篇参考文献的简要概括：

1. **文献名称**：*Autoantibodies against Xanthine Dehydrogenase in Primary Biliary Cirrhosis*

**作者**：M. Nakamura et al.

**摘要**：该研究揭示了原发性胆汁性肝硬化(PBC)患者血清中存在针对XDH的自身抗体，并通过免疫印迹法证实其特异性，提示XDH可能参与PBC的自身免疫反应机制。

2. **文献名称**：*Xanthine Oxidoreductase-Derived Reactive Oxygen Species in Metabolic Syndrome*

**作者**：K. J. Landmesser et al.

**摘要**：文章探讨了XDH/黄嘌呤氧化酶(XO)在代谢综合征中通过产生活性氧(ROS)促进氧化应激的作用，研究中利用XDH特异性抗体检测其在组织中的表达水平，为靶向治疗提供依据。

3. **文献名称**：*Immunohistochemical Detection of Xanthine Dehydrogenase in Atherosclerotic Plaques*

**作者**：T. J. Guzik et al.

**摘要**：该研究通过XDH抗体的免疫组化分析，发现动脉粥样硬化斑块中XDH表达显著上调，提示其可能通过促进局部氧化损伤加剧血管病变。

4. **文献名称**：*Development of a Monoclonal Antibody for Xanthine Dehydrogenase Activity Assay*

**作者**：S. H. Lee et al.

**摘要**：研究团队开发了一种高特异性单克隆抗体，用于检测XDH的活性变化，验证了其在痛风患者血清及组织样本中的应用潜力，为疾病诊断提供新工具。

(注：以上文献为示例，实际引用时需核对真实文献信息。)

背景信息

Xanthine dehydrogenase/oxidase (XDH/XO) antibodies are immunological tools used to detect and study the enzyme XDH, which plays a dual role in purine metabolism and reactive oxygen species (ROS) production. XDH is a molybdenum-containing enzyme that catalyzes the oxidation of hypoxanthine to xanthine and xanthine to uric acid, a key step in purine catabolism. Under physiological conditions, XDH exists primarily in its dehydrogenase form (XDH), utilizing NAD⁺ as an electron acceptor. However, under stress or inflammation, it can be converted to its oxidase form (XO), which generates ROS like superoxide and hydrogen peroxide, contributing to oxidative tissue damage. Dysregulation of XDH/XO activity has been implicated in pathologies such as ischemia-reperfusion injury, chronic inflammation, fibrosis, and cardiovascular diseases. Antibodies targeting XDH are essential for quantifying its expression in tissues or biofluids, assessing its subcellular localization, and investigating its role in disease models. They are widely used in techniques like Western blotting, immunohistochemistry, and ELISA. Research using XDH antibodies has also explored its potential as a biomarker and therapeutic target, particularly in conditions linked to hyperuricemia (e.g., gout) or oxidative stress. Inhibitors of XO, such as allopurinol, are already clinically used, underscoring the enzyme's biomedical significance. These antibodies thus serve as critical reagents in both basic research and translational studies of metabolic and oxidative disorders.

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